| Modifier | Substrate | Residue | Sequence | Mechanism/Effect | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| SIK3 | CRTC2 | Ser348 | PSLQSSLsNPNLQAS | phosphorylation down-regulates activity | 16306228 | SIGNOR-249170 |
| SIK1 | CRTC2 | Ser348 | PSLQSSLsNPNLQAS | phosphorylation down-regulates activity | 16306228 | SIGNOR-249168 |
| Enzyme | Effect | Phosphosite | Effect | Target | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| SIK3 | phosphorylation up-regulates → | CRTC2 PSer348 | phosphorylation down-regulates ⊣ | CRTC2 | 16306228 | SIGNOR-249170 |
| SIK1 | phosphorylation up-regulates → | CRTC2 PSer348 | phosphorylation down-regulates ⊣ | CRTC2 | 16306228 | SIGNOR-249168 |
| Regulator | Mechanism/Effect | Target | SIGNOR-ID |
|---|---|---|---|
| SIK3 | phosphorylation → down-regulates activity | CRTC2 | SIGNOR-249170 |
| SIK1 | phosphorylation → down-regulates activity | CRTC2 | SIGNOR-249168 |