| Modifier | Substrate | Residue | Sequence | Mechanism/Effect | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| TTK | CDCA8 | Thr94 | ATADLDItEINKLTA | phosphorylation up-regulates | 19530738 | SIGNOR-186155 |
| AURKB | CDCA8 | Ser275 | RLAQICSsIRTHK | phosphorylation up-regulates activity | 17483322 | SIGNOR-279506 |
| TTK | CDCA8 | – | phosphorylation up-regulates | 18243099 | SIGNOR-160604 | |
| TTK | CDCA8 | Thr169 | KRSSRANtVTPAVGR | phosphorylation up-regulates | 19530738 | SIGNOR-186143 |
| TTK | CDCA8 | Thr230 | DSKEIFLtVPVGGGE | phosphorylation up-regulates | 19530738 | SIGNOR-186147 |
| TTK | CDCA8 | Thr88 | QALEEAAtADLDITE | phosphorylation up-regulates | 19530738 | SIGNOR-186151 |
| Enzyme | Effect | Phosphosite | Effect | Target | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| TTK | phosphorylation up-regulates → | CDCA8 PThr94 | phosphorylation up-regulates → | CDCA8 | 19530738 | SIGNOR-186155 |
| AURKB | phosphorylation up-regulates → | CDCA8 PSer275 | phosphorylation up-regulates → | CDCA8 | 17483322 | SIGNOR-279506 |
| TTK | phosphorylation up-regulates → | CDCA8 PThr169 | phosphorylation up-regulates → | CDCA8 | 19530738 | SIGNOR-186143 |
| TTK | phosphorylation up-regulates → | CDCA8 PThr230 | phosphorylation up-regulates → | CDCA8 | 19530738 | SIGNOR-186147 |
| TTK | phosphorylation up-regulates → | CDCA8 PThr88 | phosphorylation up-regulates → | CDCA8 | 19530738 | SIGNOR-186151 |
| Regulator | Mechanism/Effect | Target | SIGNOR-ID |
|---|---|---|---|
| TTK | phosphorylation → up-regulates | CDCA8 | SIGNOR-186155 |
| AURKB | phosphorylation → up-regulates activity | CDCA8 | SIGNOR-279506 |
| TTK | phosphorylation → up-regulates | CDCA8 | SIGNOR-160604 |
| TTK | phosphorylation → up-regulates | CDCA8 | SIGNOR-186143 |
| TTK | phosphorylation → up-regulates | CDCA8 | SIGNOR-186147 |
| TTK | phosphorylation → up-regulates | CDCA8 | SIGNOR-186151 |
