| Name | TTBK1 |
| ID | Q5TCY1 |
| Role | kinase |
| Enzymatic Domains |
Protein kinase 34-297 PROSITE-ProRule |
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| Modifier | Substrate | Residue | Sequence | Mechanism/Effect | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| TTBK1 | MAPT | Ser515 | SGDRSGYsSPGSPGT | phosphorylation down-regulates | 16923168 | SIGNOR-148966 |
| TTBK1 | MAPT | Ser516 | GDRSGYSsPGSPGTP | phosphorylation down-regulates | 16923168 | SIGNOR-148970 |
| TTBK1 | MAPT | Ser519 | SGYSSPGsPGTPGSR | phosphorylation down-regulates | 16923168 | SIGNOR-148974 |
| TTBK1 | MAPT | Ser739 | GSIDMVDsPQLATLA | phosphorylation down-regulates | 16923168 | SIGNOR-148978 |
| TTBK1 | DPYSL2 | Thr514 | SVTPKTVtPASSAKT | phosphorylation up-regulates activity | 32019603 | SIGNOR-279313 |
| Enzyme | Effect | Phosphosite | Effect | Target | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| TTBK1 | phosphorylation up-regulates → | MAPT PSer515 | phosphorylation down-regulates ⊣ | MAPT | 16923168 | SIGNOR-148966 |
| TTBK1 | phosphorylation up-regulates → | MAPT PSer516 | phosphorylation down-regulates ⊣ | MAPT | 16923168 | SIGNOR-148970 |
| TTBK1 | phosphorylation up-regulates → | MAPT PSer519 | phosphorylation down-regulates ⊣ | MAPT | 16923168 | SIGNOR-148974 |
| TTBK1 | phosphorylation up-regulates → | MAPT PSer739 | phosphorylation down-regulates ⊣ | MAPT | 16923168 | SIGNOR-148978 |
| TTBK1 | phosphorylation up-regulates → | DPYSL2 PThr514 | phosphorylation up-regulates → | DPYSL2 | 32019603 | SIGNOR-279313 |
| Regulator | Mechanism/Effect | Target | SIGNOR-ID |
|---|---|---|---|
| TTBK1 | phosphorylation down-regulates | MAPT | SIGNOR-148966 |
| TTBK1 | phosphorylation down-regulates | MAPT | SIGNOR-148970 |
| TTBK1 | phosphorylation down-regulates | MAPT | SIGNOR-148974 |
| TTBK1 | phosphorylation down-regulates | MAPT | SIGNOR-148978 |
| TTBK1 | phosphorylation → up-regulates activity | DPYSL2 | SIGNOR-279313 |