| Modifier | Substrate | Residue | Sequence | Mechanism/Effect | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| JAK2 | TET2 | Tyr1964 | HETSEPTyLRFIKSL | phosphorylation up-regulates activity | 30944118 | SIGNOR-277289 |
| AMPK | TET2 | Ser99 | GGIKRTVsEPSLSGLL | phosphorylation up-regulates quantity by stabilization | 30022161 | SIGNOR-256135 |
| PRKAA1 | TET2 | Ser99 | GGIKRTVsEPSLSGLL | phosphorylation up-regulates quantity by stabilization | 30022161 | SIGNOR-256134 |
| JAK2 | TET2 | Tyr1939 | CEKYGPDyVPQKSHG | phosphorylation up-regulates activity | 30944118 | SIGNOR-277290 |
| AMPK | TET2 | – | phosphorylation up-regulates activity | 31900833 | SIGNOR-260097 | |
| FGFR3 | TET2 | Tyr1902 | TRISLVFyQHKSMNE | phosphorylation down-regulates quantity by destabilization | 33097695 | SIGNOR-277535 |
| MAP2K1 | TET2 | Ser1107 | VLNNFIEsPSKLLDT | phosphorylation up-regulates quantity by stabilization | 38461173 | SIGNOR-277891 |
| Enzyme | Effect | Phosphosite | Effect | Target | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| JAK2 | phosphorylation up-regulates → | TET2 PTyr1964 | phosphorylation up-regulates → | TET2 | 30944118 | SIGNOR-277289 |
| AMPK | phosphorylation up-regulates → | TET2 PSer99 | phosphorylation up-regulates → | TET2 | 30022161 | SIGNOR-256135 |
| PRKAA1 | phosphorylation up-regulates → | TET2 PSer99 | phosphorylation up-regulates → | TET2 | 30022161 | SIGNOR-256134 |
| JAK2 | phosphorylation up-regulates → | TET2 PTyr1939 | phosphorylation up-regulates → | TET2 | 30944118 | SIGNOR-277290 |
| FGFR3 | phosphorylation up-regulates → | TET2 PTyr1902 | phosphorylation down-regulates ⊣ | TET2 | 33097695 | SIGNOR-277535 |
| MAP2K1 | phosphorylation up-regulates → | TET2 PSer1107 | phosphorylation up-regulates → | TET2 | 38461173 | SIGNOR-277891 |
| Regulator | Mechanism/Effect | Target | SIGNOR-ID |
|---|---|---|---|
| JAK2 | phosphorylation → up-regulates activity | TET2 | SIGNOR-277289 |
| AMPK | phosphorylation → up-regulates quantity by stabilization | TET2 | SIGNOR-256135 |
| PRKAA1 | phosphorylation → up-regulates quantity by stabilization | TET2 | SIGNOR-256134 |
| JAK2 | phosphorylation → up-regulates activity | TET2 | SIGNOR-277290 |
| AMPK | phosphorylation → up-regulates activity | TET2 | SIGNOR-260097 |
| FGFR3 | phosphorylation down-regulates quantity by destabilization | TET2 | SIGNOR-277535 |
| MAP2K1 | phosphorylation → up-regulates quantity by stabilization | TET2 | SIGNOR-277891 |
