| Modifier | Substrate | Residue | Sequence | Mechanism/Effect | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| AMPK | TET2 | Ser99 | GGIKRTVsEPSLSGLL | phosphorylation up-regulates quantity by stabilization | 30022161 | SIGNOR-256135 |
| PRKAA1 | TET2 | Ser99 | GGIKRTVsEPSLSGLL | phosphorylation up-regulates quantity by stabilization | 30022161 | SIGNOR-256134 |
| Enzyme | Effect | Phosphosite | Effect | Target | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| AMPK | phosphorylation up-regulates → | TET2 PSer99 | phosphorylation up-regulates → | TET2 | 30022161 | SIGNOR-256135 |
| PRKAA1 | phosphorylation up-regulates → | TET2 PSer99 | phosphorylation up-regulates → | TET2 | 30022161 | SIGNOR-256134 |
| Regulator | Mechanism/Effect | Target | SIGNOR-ID |
|---|---|---|---|
| AMPK | phosphorylation → up-regulates quantity by stabilization | TET2 | SIGNOR-256135 |
| PRKAA1 | phosphorylation → up-regulates quantity by stabilization | TET2 | SIGNOR-256134 |