Entity Details

Name ZNF746
ID Q6NUN9
Role substrate
Enzymatic Domains
KRAB 96-167
PROSITE-ProRule
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Data Summary
PTM Format
SIGNOR Summary
Modifier Substrate Residue Sequence Mechanism/Effect PMID Interaction ID
PINK1ZNF746Ser613APPDPFKsPASKGPLphosphorylation
down-regulates quantity by destabilization		28122242SIGNOR-273725
PINK1ZNF746Ser613APPDPFKsPASKGPLphosphorylation
up-regulates activity		32169097SIGNOR-278267
PINK1ZNF746Ser322
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QATRFFPsPAQEGAWphosphorylation
up-regulates activity		32169097SIGNOR-278268
PINK1ZNF746Ser322
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QATRFFPsPAQEGAWphosphorylation
down-regulates quantity by destabilization		28122242SIGNOR-273724
ABL1ZNF746Tyr137ETLVSLDyAISKPEVphosphorylation
up-regulates activity		34581802SIGNOR-277626
Enzyme Effect Phosphosite Effect Target PMID Interaction ID
PINK1phosphorylation
up-regulates
→
ZNF746
PSer613		phosphorylation
down-regulates
⊣		ZNF74628122242SIGNOR-273725
PINK1phosphorylation
up-regulates
→
ZNF746
PSer613		phosphorylation
up-regulates
→		ZNF74632169097SIGNOR-278267
PINK1phosphorylation
up-regulates
→
ZNF746
PSer322		phosphorylation
up-regulates
→		ZNF74632169097SIGNOR-278268
PINK1phosphorylation
up-regulates
→
ZNF746
PSer322		phosphorylation
down-regulates
⊣		ZNF74628122242SIGNOR-273724
ABL1phosphorylation
up-regulates
→
ZNF746
PTyr137		phosphorylation
up-regulates
→		ZNF74634581802SIGNOR-277626
Regulator Mechanism/Effect Target SIGNOR-ID
PINK1phosphorylation
img/direct_inhibition.png
down-regulates quantity by destabilization 		ZNF746SIGNOR-273725
PINK1phosphorylation
→
up-regulates activity 		ZNF746SIGNOR-278267
PINK1phosphorylation
→
up-regulates activity 		ZNF746SIGNOR-278268
PINK1phosphorylation
img/direct_inhibition.png
down-regulates quantity by destabilization 		ZNF746SIGNOR-273724
ABL1phosphorylation
→
up-regulates activity 		ZNF746SIGNOR-277626