| Modifier | Substrate | Residue | Sequence | Mechanism/Effect | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| PLK1 | BORA | Ser497 | SSNIQMDsGYNTQNC | phosphorylation down-regulates | 18378770 | SIGNOR-178150 |
| PLK1 | BORA | Ser497 | SSNIQMDsGYNTQNC | phosphorylation down-regulates | 18521620 | SIGNOR-178803 |
| PLK1 | BORA | Thr501 | QMDSGYNtQNCGSNI | phosphorylation down-regulates | 18521620 | SIGNOR-178807 |
| CyclinA2/CDK1 | BORA | – | phosphorylation up-regulates activity | 29870721 | SIGNOR-267573 | |
| CyclinB/CDK1 | BORA | – | phosphorylation up-regulates activity | 18521620 | SIGNOR-178799 | |
| PLK1 | BORA | Thr501 | QMDSGYNtQNCGSNI | phosphorylation down-regulates | 18378770 | SIGNOR-178154 |
| GSK3B | BORA | Ser278 | PISSPTFsPIEFQIG | phosphorylation up-regulates | 23442801 | SIGNOR-201519 |
| GSK3B | BORA | Ser274 | TSPSPISsPTFSPIE | phosphorylation up-regulates | 23442801 | SIGNOR-201515 |
| Enzyme | Effect | Phosphosite | Effect | Target | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| PLK1 | phosphorylation up-regulates → | BORA PSer497 | phosphorylation down-regulates ⊣ | BORA | 18378770 | SIGNOR-178150 |
| PLK1 | phosphorylation up-regulates → | BORA PSer497 | phosphorylation down-regulates ⊣ | BORA | 18521620 | SIGNOR-178803 |
| PLK1 | phosphorylation up-regulates → | BORA PThr501 | phosphorylation down-regulates ⊣ | BORA | 18521620 | SIGNOR-178807 |
| PLK1 | phosphorylation up-regulates → | BORA PThr501 | phosphorylation down-regulates ⊣ | BORA | 18378770 | SIGNOR-178154 |
| GSK3B | phosphorylation up-regulates → | BORA PSer278 | phosphorylation up-regulates → | BORA | 23442801 | SIGNOR-201519 |
| GSK3B | phosphorylation up-regulates → | BORA PSer274 | phosphorylation up-regulates → | BORA | 23442801 | SIGNOR-201515 |
| Regulator | Mechanism/Effect | Target | SIGNOR-ID |
|---|---|---|---|
| PLK1 | phosphorylation down-regulates | BORA | SIGNOR-178150 |
| PLK1 | phosphorylation down-regulates | BORA | SIGNOR-178803 |
| PLK1 | phosphorylation down-regulates | BORA | SIGNOR-178807 |
| CyclinA2/CDK1 | phosphorylation → up-regulates activity | BORA | SIGNOR-267573 |
| CyclinB/CDK1 | phosphorylation → up-regulates activity | BORA | SIGNOR-178799 |
| PLK1 | phosphorylation down-regulates | BORA | SIGNOR-178154 |
| GSK3B | phosphorylation → up-regulates | BORA | SIGNOR-201519 |
| GSK3B | phosphorylation → up-regulates | BORA | SIGNOR-201515 |
