| Modifier | Substrate | Residue | Sequence | Mechanism/Effect | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| PRKAA1 | CRTC1 | – | phosphorylation down-regulates | 21331044 | SIGNOR-172136 | |
| MAP3K1 | CRTC1 | – | phosphorylation up-regulates | 18784253 | SIGNOR-180816 | |
| SIK1 | CRTC1 | Ser167 | MTPTQPEsFSSGSQD | phosphorylation down-regulates | 16817901 | SIGNOR-147669 |
| AMPK | CRTC1 | – | phosphorylation down-regulates | 21331044 | SIGNOR-216529 |
| Enzyme | Effect | Phosphosite | Effect | Target | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| SIK1 | phosphorylation up-regulates → | CRTC1 PSer167 | phosphorylation down-regulates ⊣ | CRTC1 | 16817901 | SIGNOR-147669 |
| Regulator | Mechanism/Effect | Target | SIGNOR-ID |
|---|---|---|---|
| PRKAA1 | phosphorylation![]() down-regulates | CRTC1 | SIGNOR-172136 |
| MAP3K1 | phosphorylation → up-regulates | CRTC1 | SIGNOR-180816 |
| SIK1 | phosphorylation![]() down-regulates | CRTC1 | SIGNOR-147669 |
| AMPK | phosphorylation![]() down-regulates | CRTC1 | SIGNOR-216529 |