Modifier	Substrate	Residue	Sequence	Mechanism/Effect	PMID	Interaction ID
PHLPP2	PRKCB	Ser661	QNEFAGFsYTNPEFV	dephosphorylation down-regulates quantity	18162466	SIGNOR-237039
PHLPP2	PRKCB	Ser661	QNEFAGFsYTNPEFV	dephosphorylation down-regulates quantity by destabilization	18162466	SIGNOR-248727
PHLPP2	PRKCA	Ser657	QSDFEGFsYVNPQFV	dephosphorylation down-regulates quantity	18162466	SIGNOR-237051
PHLPP2	RPS6KB1	Thr390	DSKFTRQtPVDSPDD	dephosphorylation down-regulates activity	21986499	SIGNOR-248247
PHLPP2	AKT1	Ser473	RPHFPQFsYSASGTA	dephosphorylation down-regulates	15808505	SIGNOR-252602
PHLPP2	AKT1	Ser473	RPHFPQFsYSASGTA	dephosphorylation down-regulates activity	19261608	SIGNOR-248728
PHLPP2	AKT2	Ser474	RTHFPQFsYSASIRE	dephosphorylation down-regulates activity	19261608	SIGNOR-248729
PHLPP2	STK4	Thr387	TMKRRDEtMQPAKPS	dephosphorylation up-regulates activity	20513427	SIGNOR-248730
PHLPP2	AKT3	Ser472	RPHFPQFsYSASGRE	dephosphorylation down-regulates activity	17386267	SIGNOR-237439
PHLPP2	AKT3	Ser472	RPHFPQFsYSASGRE	dephosphorylation down-regulates activity	19261608	SIGNOR-248731
PHLPP2	AKT	Ser473	RPHFPQFsYSASGTA	dephosphorylation down-regulates	15808505	SIGNOR-135046
PHLPP2	AKT	–		dephosphorylation down-regulates activity	19261608	SIGNOR-248732

Enzyme	Effect	Phosphosite	Effect	Target	PMID	Interaction ID
PHLPP2	dephosphorylation down-regulates ⊣	PRKCB PSer661	dephosphorylation up-regulates →	PRKCB	18162466	SIGNOR-237039
PHLPP2	dephosphorylation down-regulates ⊣	PRKCB PSer661	dephosphorylation up-regulates →	PRKCB	18162466	SIGNOR-248727
PHLPP2	dephosphorylation down-regulates ⊣	PRKCA PSer657	dephosphorylation up-regulates →	PRKCA	18162466	SIGNOR-237051
PHLPP2	dephosphorylation down-regulates ⊣	RPS6KB1 PThr390	dephosphorylation up-regulates →	RPS6KB1	21986499	SIGNOR-248247
PHLPP2	dephosphorylation down-regulates ⊣	AKT1 PSer473	dephosphorylation up-regulates →	AKT1	15808505	SIGNOR-252602
PHLPP2	dephosphorylation down-regulates ⊣	AKT1 PSer473	dephosphorylation up-regulates →	AKT1	19261608	SIGNOR-248728
PHLPP2	dephosphorylation down-regulates ⊣	AKT2 PSer474	dephosphorylation up-regulates →	AKT2	19261608	SIGNOR-248729
PHLPP2	dephosphorylation down-regulates ⊣	STK4 PThr387	dephosphorylation down-regulates ⊣	STK4	20513427	SIGNOR-248730
PHLPP2	dephosphorylation down-regulates ⊣	AKT3 PSer472	dephosphorylation up-regulates →	AKT3	17386267	SIGNOR-237439
PHLPP2	dephosphorylation down-regulates ⊣	AKT3 PSer472	dephosphorylation up-regulates →	AKT3	19261608	SIGNOR-248731
PHLPP2	dephosphorylation down-regulates ⊣	AKT PSer473	dephosphorylation up-regulates →	AKT	15808505	SIGNOR-135046

Regulator	Mechanism/Effect	Target	SIGNOR-ID
PHLPP2	dephosphorylation → down-regulates quantity	PRKCB	SIGNOR-237039
PHLPP2	dephosphorylation down-regulates quantity by destabilization	PRKCB	SIGNOR-248727
PHLPP2	dephosphorylation → down-regulates quantity	PRKCA	SIGNOR-237051
PHLPP2	dephosphorylation → down-regulates activity	RPS6KB1	SIGNOR-248247
PHLPP2	dephosphorylation down-regulates	AKT1	SIGNOR-252602
PHLPP2	dephosphorylation → down-regulates activity	AKT1	SIGNOR-248728
PHLPP2	dephosphorylation → down-regulates activity	AKT2	SIGNOR-248729
PHLPP2	dephosphorylation → up-regulates activity	STK4	SIGNOR-248730
PHLPP2	dephosphorylation → down-regulates activity	AKT3	SIGNOR-237439
PHLPP2	dephosphorylation → down-regulates activity	AKT3	SIGNOR-248731
PHLPP2	dephosphorylation down-regulates	AKT	SIGNOR-135046
PHLPP2	dephosphorylation → down-regulates activity	AKT	SIGNOR-248732