| Name | PREX2 |
| ID | Q70Z35 |
| Role | substrate |
| Enzymatic Domains |
DH 23-214 PROSITE-ProRule
PH 245-361 PROSITE-ProRule
DEP 1 390-464 PROSITE-ProRule
DEP 2 491-566 PROSITE-ProRule
PDZ 1 592-671 PROSITE-ProRule
PDZ 2 677-754 PROSITE-ProRule |
View in  |
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| Modifier | Substrate | Residue | Sequence | Mechanism/Effect | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| PAK1 | PREX2 | Ser1107 | DTISNRDsYSDCNSN | phosphorylation down-regulates activity | 26438819 | SIGNOR-277181 |
| PPP2CA | PREX2 | Ser1107 | DTISNRDsYSDCNSN | dephosphorylation up-regulates activity | 26438819 | SIGNOR-277184 |
| PAK2 | PREX2 | Ser1107 | DTISNRDsYSDCNSN | phosphorylation down-regulates activity | 26438819 | SIGNOR-277182 |
| PPP1CA | PREX2 | Ser1107 | DTISNRDsYSDCNSN | dephosphorylation up-regulates activity | 26438819 | SIGNOR-277183 |
| Enzyme | Effect | Phosphosite | Effect | Target | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| PAK1 | phosphorylation up-regulates → | PREX2 PSer1107 | phosphorylation down-regulates ⊣ | PREX2 | 26438819 | SIGNOR-277181 |
| PPP2CA | dephosphorylation down-regulates ⊣ | PREX2 PSer1107 | dephosphorylation down-regulates ⊣ | PREX2 | 26438819 | SIGNOR-277184 |
| PAK2 | phosphorylation up-regulates → | PREX2 PSer1107 | phosphorylation down-regulates ⊣ | PREX2 | 26438819 | SIGNOR-277182 |
| PPP1CA | dephosphorylation down-regulates ⊣ | PREX2 PSer1107 | dephosphorylation down-regulates ⊣ | PREX2 | 26438819 | SIGNOR-277183 |
| Regulator | Mechanism/Effect | Target | SIGNOR-ID |
|---|---|---|---|
| PAK1 | phosphorylation → down-regulates activity | PREX2 | SIGNOR-277181 |
| PPP2CA | dephosphorylation → up-regulates activity | PREX2 | SIGNOR-277184 |
| PAK2 | phosphorylation → down-regulates activity | PREX2 | SIGNOR-277182 |
| PPP1CA | dephosphorylation → up-regulates activity | PREX2 | SIGNOR-277183 |