| Modifier | Substrate | Residue | Sequence | Mechanism/Effect | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| PAK1 | PREX2 | Ser1107 | DTISNRDsYSDCNSN | phosphorylation down-regulates activity | 26438819 | SIGNOR-277181 |
| PPP2CA | PREX2 | Ser1107 | DTISNRDsYSDCNSN | dephosphorylation up-regulates activity | 26438819 | SIGNOR-277184 |
| PAK2 | PREX2 | Ser1107 | DTISNRDsYSDCNSN | phosphorylation down-regulates activity | 26438819 | SIGNOR-277182 |
| PPP1CA | PREX2 | Ser1107 | DTISNRDsYSDCNSN | dephosphorylation up-regulates activity | 26438819 | SIGNOR-277183 |
| Enzyme | Effect | Phosphosite | Effect | Target | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| PAK1 | phosphorylation up-regulates → | PREX2 PSer1107 | phosphorylation down-regulates ⊣ | PREX2 | 26438819 | SIGNOR-277181 |
| PPP2CA | dephosphorylation down-regulates ⊣ | PREX2 PSer1107 | dephosphorylation down-regulates ⊣ | PREX2 | 26438819 | SIGNOR-277184 |
| PAK2 | phosphorylation up-regulates → | PREX2 PSer1107 | phosphorylation down-regulates ⊣ | PREX2 | 26438819 | SIGNOR-277182 |
| PPP1CA | dephosphorylation down-regulates ⊣ | PREX2 PSer1107 | dephosphorylation down-regulates ⊣ | PREX2 | 26438819 | SIGNOR-277183 |
| Regulator | Mechanism/Effect | Target | SIGNOR-ID |
|---|---|---|---|
| PAK1 | phosphorylation → down-regulates activity | PREX2 | SIGNOR-277181 |
| PPP2CA | dephosphorylation → up-regulates activity | PREX2 | SIGNOR-277184 |
| PAK2 | phosphorylation → down-regulates activity | PREX2 | SIGNOR-277182 |
| PPP1CA | dephosphorylation → up-regulates activity | PREX2 | SIGNOR-277183 |
