| Modifier | Substrate | Residue | Sequence | Mechanism/Effect | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| PLK1 | CENPQ | Ser253 | HNSSQMKsMSTFIEE | phosphorylation down-regulates quantity by destabilization | 25670858 | SIGNOR-265232 |
| PLK1 | CENPQ | Thr123 | RLLQQCEtLKVPPKK | phosphorylation down-regulates quantity by destabilization | 25670858 | SIGNOR-265231 |
| PLK1 | CENPQ | Ser139 | EDLTNVSsLLNMERA | phosphorylation down-regulates quantity by destabilization | 25670858 | SIGNOR-265233 |
| PLK1 | CENPQ | Ser138 | MEDLTNVsSLLNMER | phosphorylation down-regulates quantity by destabilization | 25670858 | SIGNOR-265228 |
| PLK1 | CENPQ | Thr135 | PKKMEDLtNVSSLLN | phosphorylation down-regulates quantity by destabilization | 25670858 | SIGNOR-265234 |
| PLK1 | CENPQ | Ser249 | LDILHNSsQMKSMST | phosphorylation down-regulates quantity by destabilization | 25670858 | SIGNOR-265230 |
| PLK1 | CENPQ | Thr256 | SQMKSMStFIEEAYK | phosphorylation down-regulates quantity by destabilization | 25670858 | SIGNOR-265229 |
| PLK1 | CENPQ | Ser255 | SSQMKSMsTFIEEAY | phosphorylation down-regulates quantity by destabilization | 25670858 | SIGNOR-265226 |
| PLK1 | CENPQ | Ser248 | DLDILHNsSQMKSMS | phosphorylation down-regulates quantity by destabilization | 25670858 | SIGNOR-265227 |
| Enzyme | Effect | Phosphosite | Effect | Target | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| PLK1 | phosphorylation up-regulates → | CENPQ PSer253 | phosphorylation down-regulates ⊣ | CENPQ | 25670858 | SIGNOR-265232 |
| PLK1 | phosphorylation up-regulates → | CENPQ PThr123 | phosphorylation down-regulates ⊣ | CENPQ | 25670858 | SIGNOR-265231 |
| PLK1 | phosphorylation up-regulates → | CENPQ PSer139 | phosphorylation down-regulates ⊣ | CENPQ | 25670858 | SIGNOR-265233 |
| PLK1 | phosphorylation up-regulates → | CENPQ PSer138 | phosphorylation down-regulates ⊣ | CENPQ | 25670858 | SIGNOR-265228 |
| PLK1 | phosphorylation up-regulates → | CENPQ PThr135 | phosphorylation down-regulates ⊣ | CENPQ | 25670858 | SIGNOR-265234 |
| PLK1 | phosphorylation up-regulates → | CENPQ PSer249 | phosphorylation down-regulates ⊣ | CENPQ | 25670858 | SIGNOR-265230 |
| PLK1 | phosphorylation up-regulates → | CENPQ PThr256 | phosphorylation down-regulates ⊣ | CENPQ | 25670858 | SIGNOR-265229 |
| PLK1 | phosphorylation up-regulates → | CENPQ PSer255 | phosphorylation down-regulates ⊣ | CENPQ | 25670858 | SIGNOR-265226 |
| PLK1 | phosphorylation up-regulates → | CENPQ PSer248 | phosphorylation down-regulates ⊣ | CENPQ | 25670858 | SIGNOR-265227 |
| Regulator | Mechanism/Effect | Target | SIGNOR-ID |
|---|---|---|---|
| PLK1 | phosphorylation down-regulates quantity by destabilization | CENPQ | SIGNOR-265232 |
| PLK1 | phosphorylation down-regulates quantity by destabilization | CENPQ | SIGNOR-265231 |
| PLK1 | phosphorylation down-regulates quantity by destabilization | CENPQ | SIGNOR-265233 |
| PLK1 | phosphorylation down-regulates quantity by destabilization | CENPQ | SIGNOR-265228 |
| PLK1 | phosphorylation down-regulates quantity by destabilization | CENPQ | SIGNOR-265234 |
| PLK1 | phosphorylation down-regulates quantity by destabilization | CENPQ | SIGNOR-265230 |
| PLK1 | phosphorylation down-regulates quantity by destabilization | CENPQ | SIGNOR-265229 |
| PLK1 | phosphorylation down-regulates quantity by destabilization | CENPQ | SIGNOR-265226 |
| PLK1 | phosphorylation down-regulates quantity by destabilization | CENPQ | SIGNOR-265227 |
