| Modifier | Substrate | Residue | Sequence | Mechanism/Effect | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| PRKACA | TRPM8 | Thr17 | MRNRRNDtLDSTRTL | phosphorylation up-regulates activity | 20110357 | SIGNOR-273791 |
| PPP2CA | TRPM8 | Thr17 | MRNRRNDtLDSTRTL | dephosphorylation down-regulates activity | 20110357 | SIGNOR-273793 |
| Enzyme | Effect | Phosphosite | Effect | Target | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| PRKACA | phosphorylation up-regulates → | TRPM8 PThr17 | phosphorylation up-regulates → | TRPM8 | 20110357 | SIGNOR-273791 |
| PPP2CA | dephosphorylation down-regulates ⊣ | TRPM8 PThr17 | dephosphorylation up-regulates → | TRPM8 | 20110357 | SIGNOR-273793 |
| Regulator | Mechanism/Effect | Target | SIGNOR-ID |
|---|---|---|---|
| PRKACA | phosphorylation → up-regulates activity | TRPM8 | SIGNOR-273791 |
| PPP2CA | dephosphorylation → down-regulates activity | TRPM8 | SIGNOR-273793 |