| Modifier | Substrate | Residue | Sequence | Mechanism/Effect | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| PRKACA | TRPM8 | Ser9 | SFRAARLsMRNRRND | phosphorylation up-regulates activity | 20110357 | SIGNOR-273792 |
| PPP2CA | TRPM8 | Ser9 | SFRAARLsMRNRRND | dephosphorylation down-regulates activity | 20110357 | SIGNOR-273794 |
| Enzyme | Effect | Phosphosite | Effect | Target | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| PRKACA | phosphorylation up-regulates → | TRPM8 PSer9 | phosphorylation up-regulates → | TRPM8 | 20110357 | SIGNOR-273792 |
| PPP2CA | dephosphorylation down-regulates ⊣ | TRPM8 PSer9 | dephosphorylation up-regulates → | TRPM8 | 20110357 | SIGNOR-273794 |
| Regulator | Mechanism/Effect | Target | SIGNOR-ID |
|---|---|---|---|
| PRKACA | phosphorylation → up-regulates activity | TRPM8 | SIGNOR-273792 |
| PPP2CA | dephosphorylation → down-regulates activity | TRPM8 | SIGNOR-273794 |