| Modifier | Substrate | Residue | Sequence | Mechanism/Effect | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| ERK1/2 | METTL3 | Ser43 | RNPEAALsPTFRSDS | phosphorylation up-regulates quantity by stabilization | 33217317 | SIGNOR-265953 |
| MAPK1 | METTL3 | Ser43 | RNPEAALsPTFRSDS | phosphorylation up-regulates quantity by stabilization | 33217317 | SIGNOR-265950 |
| MAPK3 | METTL3 | Ser50 | SPTFRSDsPVPTAPT | phosphorylation up-regulates quantity by stabilization | 33217317 | SIGNOR-265945 |
| ERK1/2 | METTL3 | Ser50 | SPTFRSDsPVPTAPT | phosphorylation up-regulates quantity by stabilization | 33217317 | SIGNOR-265951 |
| ERK1/2 | METTL3 | Ser525 | YGMIERLsPGTRKIE | phosphorylation up-regulates quantity by stabilization | 33217317 | SIGNOR-265952 |
| MAPK3 | METTL3 | Ser525 | YGMIERLsPGTRKIE | phosphorylation up-regulates quantity by stabilization | 33217317 | SIGNOR-265947 |
| MAPK1 | METTL3 | Ser50 | SPTFRSDsPVPTAPT | phosphorylation up-regulates quantity by stabilization | 33217317 | SIGNOR-265946 |
| MAPK1 | METTL3 | Ser525 | YGMIERLsPGTRKIE | phosphorylation up-regulates quantity by stabilization | 33217317 | SIGNOR-265948 |
| MAPK3 | METTL3 | Ser43 | RNPEAALsPTFRSDS | phosphorylation up-regulates quantity by stabilization | 33217317 | SIGNOR-265949 |
| ATM | METTL3 | Ser43 | RNPEAALsPTFRSDS | phosphorylation up-regulates activity | 32615088 | SIGNOR-265969 |
| TBK1 | METTL3 | – | phosphorylation up-regulates activity | 35172162 | SIGNOR-279299 | |
| Gbeta | METTL3 | – | phosphorylation up-regulates quantity by stabilization | 33217317 | SIGNOR-270035 |
| Enzyme | Effect | Phosphosite | Effect | Target | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| ERK1/2 | phosphorylation up-regulates → | METTL3 PSer43 | phosphorylation up-regulates → | METTL3 | 33217317 | SIGNOR-265953 |
| MAPK1 | phosphorylation up-regulates → | METTL3 PSer43 | phosphorylation up-regulates → | METTL3 | 33217317 | SIGNOR-265950 |
| MAPK3 | phosphorylation up-regulates → | METTL3 PSer50 | phosphorylation up-regulates → | METTL3 | 33217317 | SIGNOR-265945 |
| ERK1/2 | phosphorylation up-regulates → | METTL3 PSer50 | phosphorylation up-regulates → | METTL3 | 33217317 | SIGNOR-265951 |
| ERK1/2 | phosphorylation up-regulates → | METTL3 PSer525 | phosphorylation up-regulates → | METTL3 | 33217317 | SIGNOR-265952 |
| MAPK3 | phosphorylation up-regulates → | METTL3 PSer525 | phosphorylation up-regulates → | METTL3 | 33217317 | SIGNOR-265947 |
| MAPK1 | phosphorylation up-regulates → | METTL3 PSer50 | phosphorylation up-regulates → | METTL3 | 33217317 | SIGNOR-265946 |
| MAPK1 | phosphorylation up-regulates → | METTL3 PSer525 | phosphorylation up-regulates → | METTL3 | 33217317 | SIGNOR-265948 |
| MAPK3 | phosphorylation up-regulates → | METTL3 PSer43 | phosphorylation up-regulates → | METTL3 | 33217317 | SIGNOR-265949 |
| ATM | phosphorylation up-regulates → | METTL3 PSer43 | phosphorylation up-regulates → | METTL3 | 32615088 | SIGNOR-265969 |
| Regulator | Mechanism/Effect | Target | SIGNOR-ID |
|---|---|---|---|
| ERK1/2 | phosphorylation → up-regulates quantity by stabilization | METTL3 | SIGNOR-265953 |
| MAPK1 | phosphorylation → up-regulates quantity by stabilization | METTL3 | SIGNOR-265950 |
| MAPK3 | phosphorylation → up-regulates quantity by stabilization | METTL3 | SIGNOR-265945 |
| ERK1/2 | phosphorylation → up-regulates quantity by stabilization | METTL3 | SIGNOR-265951 |
| ERK1/2 | phosphorylation → up-regulates quantity by stabilization | METTL3 | SIGNOR-265952 |
| MAPK3 | phosphorylation → up-regulates quantity by stabilization | METTL3 | SIGNOR-265947 |
| MAPK1 | phosphorylation → up-regulates quantity by stabilization | METTL3 | SIGNOR-265946 |
| MAPK1 | phosphorylation → up-regulates quantity by stabilization | METTL3 | SIGNOR-265948 |
| MAPK3 | phosphorylation → up-regulates quantity by stabilization | METTL3 | SIGNOR-265949 |
| ATM | phosphorylation → up-regulates activity | METTL3 | SIGNOR-265969 |
| TBK1 | phosphorylation → up-regulates activity | METTL3 | SIGNOR-279299 |
| Gbeta | phosphorylation → up-regulates quantity by stabilization | METTL3 | SIGNOR-270035 |
