Modifier	Substrate	Residue	Sequence	Mechanism/Effect	PMID	Interaction ID
ERK1/2	METTL3	Ser43 View in OncoXplorer	RNPEAALsPTFRSDS	phosphorylation up-regulates quantity by stabilization	33217317	SIGNOR-265953
MAPK3	METTL3	Ser43 View in OncoXplorer	RNPEAALsPTFRSDS	phosphorylation up-regulates quantity by stabilization	33217317	SIGNOR-265949
ERK1/2	METTL3	Ser50 View in OncoXplorer	SPTFRSDsPVPTAPT	phosphorylation up-regulates quantity by stabilization	33217317	SIGNOR-265951
ERK1/2	METTL3	Ser525	YGMIERLsPGTRKIE	phosphorylation up-regulates quantity by stabilization	33217317	SIGNOR-265952
MAPK3	METTL3	Ser50 View in OncoXplorer	SPTFRSDsPVPTAPT	phosphorylation up-regulates quantity by stabilization	33217317	SIGNOR-265945
MAPK3	METTL3	Ser525	YGMIERLsPGTRKIE	phosphorylation up-regulates quantity by stabilization	33217317	SIGNOR-265947
MAPK1	METTL3	Ser43 View in OncoXplorer	RNPEAALsPTFRSDS	phosphorylation up-regulates quantity by stabilization	33217317	SIGNOR-265950
ATM	METTL3	Ser43 View in OncoXplorer	RNPEAALsPTFRSDS	phosphorylation up-regulates activity	32615088	SIGNOR-265969
Gbeta	METTL3	–		phosphorylation up-regulates quantity by stabilization	33217317	SIGNOR-270035
TBK1	METTL3	–		phosphorylation up-regulates activity	35172162	SIGNOR-279299
MAPK1	METTL3	Ser525	YGMIERLsPGTRKIE	phosphorylation up-regulates quantity by stabilization	33217317	SIGNOR-265948
MAPK1	METTL3	Ser50 View in OncoXplorer	SPTFRSDsPVPTAPT	phosphorylation up-regulates quantity by stabilization	33217317	SIGNOR-265946

Enzyme	Effect	Phosphosite	Effect	Target	PMID	Interaction ID
ERK1/2	phosphorylation up-regulates →	METTL3 PSer43	phosphorylation up-regulates →	METTL3	33217317	SIGNOR-265953
MAPK3	phosphorylation up-regulates →	METTL3 PSer43	phosphorylation up-regulates →	METTL3	33217317	SIGNOR-265949
ERK1/2	phosphorylation up-regulates →	METTL3 PSer50	phosphorylation up-regulates →	METTL3	33217317	SIGNOR-265951
ERK1/2	phosphorylation up-regulates →	METTL3 PSer525	phosphorylation up-regulates →	METTL3	33217317	SIGNOR-265952
MAPK3	phosphorylation up-regulates →	METTL3 PSer50	phosphorylation up-regulates →	METTL3	33217317	SIGNOR-265945
MAPK3	phosphorylation up-regulates →	METTL3 PSer525	phosphorylation up-regulates →	METTL3	33217317	SIGNOR-265947
MAPK1	phosphorylation up-regulates →	METTL3 PSer43	phosphorylation up-regulates →	METTL3	33217317	SIGNOR-265950
ATM	phosphorylation up-regulates →	METTL3 PSer43	phosphorylation up-regulates →	METTL3	32615088	SIGNOR-265969
MAPK1	phosphorylation up-regulates →	METTL3 PSer525	phosphorylation up-regulates →	METTL3	33217317	SIGNOR-265948
MAPK1	phosphorylation up-regulates →	METTL3 PSer50	phosphorylation up-regulates →	METTL3	33217317	SIGNOR-265946

Regulator	Mechanism/Effect	Target	SIGNOR-ID
ERK1/2	phosphorylation → up-regulates quantity by stabilization	METTL3	SIGNOR-265953
MAPK3	phosphorylation → up-regulates quantity by stabilization	METTL3	SIGNOR-265949
ERK1/2	phosphorylation → up-regulates quantity by stabilization	METTL3	SIGNOR-265951
ERK1/2	phosphorylation → up-regulates quantity by stabilization	METTL3	SIGNOR-265952
MAPK3	phosphorylation → up-regulates quantity by stabilization	METTL3	SIGNOR-265945
MAPK3	phosphorylation → up-regulates quantity by stabilization	METTL3	SIGNOR-265947
MAPK1	phosphorylation → up-regulates quantity by stabilization	METTL3	SIGNOR-265950
ATM	phosphorylation → up-regulates activity	METTL3	SIGNOR-265969
Gbeta	phosphorylation → up-regulates quantity by stabilization	METTL3	SIGNOR-270035
TBK1	phosphorylation → up-regulates activity	METTL3	SIGNOR-279299
MAPK1	phosphorylation → up-regulates quantity by stabilization	METTL3	SIGNOR-265948
MAPK1	phosphorylation → up-regulates quantity by stabilization	METTL3	SIGNOR-265946