Modifier	Substrate	Residue	Sequence	Mechanism/Effect	PMID	Interaction ID
VRK2	BANF1	Ser4	sQKHRDFV	phosphorylation down-regulates	16371512	SIGNOR-143368
VRK2	BANF1	Ser4	sQKHRDFV	phosphorylation down-regulates	16495336	SIGNOR-144795
VRK2	BANF1	Thr2	tTSQKHRD	phosphorylation down-regulates	16495336	SIGNOR-144799
VRK2	BANF1	Thr3	tSQKHRDF	phosphorylation down-regulates	16495336	SIGNOR-144803
VRK2	GAPDH	Ser151	LKIISNAsCTTNCLA	phosphorylation up-regulates activity	37450367	SIGNOR-277840
VRK2	TP53	Thr18	EPPLSQEtFSDLWKL	phosphorylation up-regulates activity	16704422	SIGNOR-280162
VRK2	TKT	Thr287	SKKKILAtPPQEDAP	phosphorylation up-regulates activity	37653031	SIGNOR-277842
VRK2	NFATC2	Ser31	PQDELDFsILFDYEY	phosphorylation up-regulates	23105117	SIGNOR-199263
VRK2	DTNBP1	Ser297	ELRAKPPsSSSTCTD	phosphorylation down-regulates quantity by destabilization	30062698	SIGNOR-277403
VRK2	DTNBP1	Ser299	RAKPPSSsSTCTDSA	phosphorylation down-regulates quantity by destabilization	30062698	SIGNOR-277404
VRK2	USP25	Ser745	PEYLEQPsRSDFSKH	phosphorylation down-regulates activity	25755282	SIGNOR-273579
VRK2	USP25	Thr680	QPLVGIEtLPPDLRD	phosphorylation down-regulates activity	25755282	SIGNOR-273580
VRK2	USP25	Thr727	QKLRESEtSVTTAQA	phosphorylation down-regulates activity	25755282	SIGNOR-273578
VRK2	FBXW2	–		phosphorylation down-regulates activity	28090088	SIGNOR-280161

Enzyme	Effect	Phosphosite	Effect	Target	PMID	Interaction ID
VRK2	phosphorylation up-regulates →	BANF1 PSer4	phosphorylation down-regulates ⊣	BANF1	16371512	SIGNOR-143368
VRK2	phosphorylation up-regulates →	BANF1 PSer4	phosphorylation down-regulates ⊣	BANF1	16495336	SIGNOR-144795
VRK2	phosphorylation up-regulates →	BANF1 PThr2	phosphorylation down-regulates ⊣	BANF1	16495336	SIGNOR-144799
VRK2	phosphorylation up-regulates →	BANF1 PThr3	phosphorylation down-regulates ⊣	BANF1	16495336	SIGNOR-144803
VRK2	phosphorylation up-regulates →	GAPDH PSer151	phosphorylation up-regulates →	GAPDH	37450367	SIGNOR-277840
VRK2	phosphorylation up-regulates →	TP53 PThr18	phosphorylation up-regulates →	TP53	16704422	SIGNOR-280162
VRK2	phosphorylation up-regulates →	TKT PThr287	phosphorylation up-regulates →	TKT	37653031	SIGNOR-277842
VRK2	phosphorylation up-regulates →	NFATC2 PSer31	phosphorylation up-regulates →	NFATC2	23105117	SIGNOR-199263
VRK2	phosphorylation up-regulates →	DTNBP1 PSer297	phosphorylation down-regulates ⊣	DTNBP1	30062698	SIGNOR-277403
VRK2	phosphorylation up-regulates →	DTNBP1 PSer299	phosphorylation down-regulates ⊣	DTNBP1	30062698	SIGNOR-277404
VRK2	phosphorylation up-regulates →	USP25 PSer745	phosphorylation down-regulates ⊣	USP25	25755282	SIGNOR-273579
VRK2	phosphorylation up-regulates →	USP25 PThr680	phosphorylation down-regulates ⊣	USP25	25755282	SIGNOR-273580
VRK2	phosphorylation up-regulates →	USP25 PThr727	phosphorylation down-regulates ⊣	USP25	25755282	SIGNOR-273578

Regulator	Mechanism/Effect	Target	SIGNOR-ID
VRK2	phosphorylation down-regulates	BANF1	SIGNOR-143368
VRK2	phosphorylation down-regulates	BANF1	SIGNOR-144795
VRK2	phosphorylation down-regulates	BANF1	SIGNOR-144799
VRK2	phosphorylation down-regulates	BANF1	SIGNOR-144803
VRK2	phosphorylation → up-regulates activity	GAPDH	SIGNOR-277840
VRK2	phosphorylation → up-regulates activity	TP53	SIGNOR-280162
VRK2	phosphorylation → up-regulates activity	TKT	SIGNOR-277842
VRK2	phosphorylation → up-regulates	NFATC2	SIGNOR-199263
VRK2	phosphorylation down-regulates quantity by destabilization	DTNBP1	SIGNOR-277403
VRK2	phosphorylation down-regulates quantity by destabilization	DTNBP1	SIGNOR-277404
VRK2	phosphorylation → down-regulates activity	USP25	SIGNOR-273579
VRK2	phosphorylation → down-regulates activity	USP25	SIGNOR-273580
VRK2	phosphorylation → down-regulates activity	USP25	SIGNOR-273578
VRK2	phosphorylation → down-regulates activity	FBXW2	SIGNOR-280161