| Modifier | Substrate | Residue | Sequence | Mechanism/Effect | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| NME1 | KSR1 | Ser406 | TRLRRTEsVPSDINN | phosphorylation down-regulates | 12105213 | SIGNOR-90390 |
| MARK3 | KSR1 | Ser406 | TRLRRTEsVPSDINN | phosphorylation down-regulates activity | 22206009 | SIGNOR-279225 |
| MARK2 | KSR1 | Ser406 | TRLRRTEsVPSDINN | phosphorylation down-regulates activity | 22206009 | SIGNOR-279343 |
| NME1 | KSR1 | Ser406 | TRLRRTEsVPSDINN | phosphorylation unknown | 12105213 | SIGNOR-250299 |
| MAP3K7 | KSR1 | Ser406 | TRLRRTEsVPSDINN | phosphorylation down-regulates | 11741534 | SIGNOR-112779 |
| Enzyme | Effect | Phosphosite | Effect | Target | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| NME1 | phosphorylation up-regulates → | KSR1 PSer406 | phosphorylation down-regulates ⊣ | KSR1 | 12105213 | SIGNOR-90390 |
| MARK3 | phosphorylation up-regulates → | KSR1 PSer406 | phosphorylation down-regulates ⊣ | KSR1 | 22206009 | SIGNOR-279225 |
| MARK2 | phosphorylation up-regulates → | KSR1 PSer406 | phosphorylation down-regulates ⊣ | KSR1 | 22206009 | SIGNOR-279343 |
| NME1 | phosphorylation up-regulates → | KSR1 PSer406 | phosphorylation down-regulates ⊣ | KSR1 | 12105213 | SIGNOR-250299 |
| MAP3K7 | phosphorylation up-regulates → | KSR1 PSer406 | phosphorylation down-regulates ⊣ | KSR1 | 11741534 | SIGNOR-112779 |
| Regulator | Mechanism/Effect | Target | SIGNOR-ID |
|---|---|---|---|
| NME1 | phosphorylation down-regulates | KSR1 | SIGNOR-90390 |
| MARK3 | phosphorylation → down-regulates activity | KSR1 | SIGNOR-279225 |
| MARK2 | phosphorylation → down-regulates activity | KSR1 | SIGNOR-279343 |
| NME1 | phosphorylation → unknown | KSR1 | SIGNOR-250299 |
| MAP3K7 | phosphorylation down-regulates | KSR1 | SIGNOR-112779 |
