Modifier	Substrate	Residue	Sequence	Mechanism/Effect	PMID	Interaction ID
MAPKAPK5	EEF2K	Ser377	PPLLRPLsENSGDEN	phosphorylation unknown	12171600	SIGNOR-249708
MAPKAPK5	FOXO3	Ser215	NSIRHNLsLHSRFMR	phosphorylation up-regulates activity	21329882	SIGNOR-279469
MAPKAPK5	KALRN	Ser487	DVLQRPLsPGNSESL	phosphorylation up-regulates activity	22508986	SIGNOR-263093
MAPKAPK5	TP53	Ser37	NVLSPLPsQAMDDLM	phosphorylation up-regulates	17254968	SIGNOR-152847
MAPKAPK5	TP53	–		phosphorylation up-regulates	17254968	SIGNOR-152850
MAPKAPK5	JUN	Ser63	KNSDLLTsPDVGLLK	phosphorylation up-regulates activity	32690100	SIGNOR-279422
MAPKAPK5	TH	Ser19	KGFRRAVsELDAKQA	phosphorylation up-regulates	12421349	SIGNOR-95479
MAPKAPK5	DNAJB1	Ser149	TNVNFGRsRSAQEPA	phosphorylation up-regulates	24309468	SIGNOR-203456
MAPKAPK5	DNAJB1	Ser151	VNFGRSRsAQEPARK	phosphorylation up-regulates	24309468	SIGNOR-203460
MAPKAPK5	DNAJB1	Ser171	VTHDLRVsLEEIYSG	phosphorylation up-regulates	24309468	SIGNOR-203464
MAPKAPK5	MAPK4	Ser186	YSHKGYLsEGLVTKW	phosphorylation up-regulates	1319925	SIGNOR-17069
MAPKAPK5	PLA2G4A	Ser727	RQNPSRCsVSLSNVE	phosphorylation up-regulates activity	10978317	SIGNOR-250162
MAPKAPK5	FOXO1	–		phosphorylation up-regulates activity	23878308	SIGNOR-280037
MAPKAPK5	RHEB	Ser130	LHMERVIsYEEGKAL	phosphorylation down-regulates activity	21336308	SIGNOR-276313
MAPKAPK5	PARK7	–		phosphorylation up-regulates activity	25383140	SIGNOR-279746

Enzyme	Effect	Phosphosite	Effect	Target	PMID	Interaction ID
MAPKAPK5	phosphorylation up-regulates →	EEF2K PSer377	phosphorylation down-regulates ⊣	EEF2K	12171600	SIGNOR-249708
MAPKAPK5	phosphorylation up-regulates →	FOXO3 PSer215	phosphorylation up-regulates →	FOXO3	21329882	SIGNOR-279469
MAPKAPK5	phosphorylation up-regulates →	KALRN PSer487	phosphorylation up-regulates →	KALRN	22508986	SIGNOR-263093
MAPKAPK5	phosphorylation up-regulates →	TP53 PSer37	phosphorylation up-regulates →	TP53	17254968	SIGNOR-152847
MAPKAPK5	phosphorylation up-regulates →	JUN PSer63	phosphorylation up-regulates →	JUN	32690100	SIGNOR-279422
MAPKAPK5	phosphorylation up-regulates →	TH PSer19	phosphorylation up-regulates →	TH	12421349	SIGNOR-95479
MAPKAPK5	phosphorylation up-regulates →	DNAJB1 PSer149	phosphorylation up-regulates →	DNAJB1	24309468	SIGNOR-203456
MAPKAPK5	phosphorylation up-regulates →	DNAJB1 PSer151	phosphorylation up-regulates →	DNAJB1	24309468	SIGNOR-203460
MAPKAPK5	phosphorylation up-regulates →	DNAJB1 PSer171	phosphorylation up-regulates →	DNAJB1	24309468	SIGNOR-203464
MAPKAPK5	phosphorylation up-regulates →	MAPK4 PSer186	phosphorylation up-regulates →	MAPK4	1319925	SIGNOR-17069
MAPKAPK5	phosphorylation up-regulates →	PLA2G4A PSer727	phosphorylation up-regulates →	PLA2G4A	10978317	SIGNOR-250162
MAPKAPK5	phosphorylation up-regulates →	RHEB PSer130	phosphorylation down-regulates ⊣	RHEB	21336308	SIGNOR-276313

Regulator	Mechanism/Effect	Target	SIGNOR-ID
MAPKAPK5	phosphorylation → unknown	EEF2K	SIGNOR-249708
MAPKAPK5	phosphorylation → up-regulates activity	FOXO3	SIGNOR-279469
MAPKAPK5	phosphorylation → up-regulates activity	KALRN	SIGNOR-263093
MAPKAPK5	phosphorylation → up-regulates	TP53	SIGNOR-152847
MAPKAPK5	phosphorylation → up-regulates	TP53	SIGNOR-152850
MAPKAPK5	phosphorylation → up-regulates activity	JUN	SIGNOR-279422
MAPKAPK5	phosphorylation → up-regulates	TH	SIGNOR-95479
MAPKAPK5	phosphorylation → up-regulates	DNAJB1	SIGNOR-203456
MAPKAPK5	phosphorylation → up-regulates	DNAJB1	SIGNOR-203460
MAPKAPK5	phosphorylation → up-regulates	DNAJB1	SIGNOR-203464
MAPKAPK5	phosphorylation → up-regulates	MAPK4	SIGNOR-17069
MAPKAPK5	phosphorylation → up-regulates activity	PLA2G4A	SIGNOR-250162
MAPKAPK5	phosphorylation → up-regulates activity	FOXO1	SIGNOR-280037
MAPKAPK5	phosphorylation → down-regulates activity	RHEB	SIGNOR-276313
MAPKAPK5	phosphorylation → up-regulates activity	PARK7	SIGNOR-279746