| Name | MAPKAPK5 |
| ID | Q8IW41 |
| Role | substrate |
| Enzymatic Domains |
Protein kinase 22-304 PROSITE-ProRule |
View in  |
|
| Modifier | Substrate | Residue | Sequence | Mechanism/Effect | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| MAPK11 | MAPKAPK5 | Thr182 | IDQGDLMtPQFTPYY | phosphorylation up-regulates | 9628874 | SIGNOR-58131 |
| MAPK1 | MAPKAPK5 | Thr182 | IDQGDLMtPQFTPYY | phosphorylation up-regulates | 9628874 | SIGNOR-58127 |
| MAPK4 | MAPKAPK5 | Thr182 | IDQGDLMtPQFTPYY | phosphorylation up-regulates activity | 20734105 | SIGNOR-279072 |
| TLK1 | MAPKAPK5 | Ser386 | HENGAEDsNVALEKL | phosphorylation up-regulates activity | 35064619 | SIGNOR-276747 |
| TLK1 | MAPKAPK5 | Ser160 | NLLFKDNsLDAPVKL | phosphorylation up-regulates activity | 35064619 | SIGNOR-276745 |
| SRC | MAPKAPK5 | Tyr188 | MTPQFTPyYVAPQVL | phosphorylation up-regulates quantity | 26042227 | SIGNOR-279761 |
| SRC | MAPKAPK5 | Tyr216 | IPTSPTPyTYNKSCD | phosphorylation up-regulates quantity | 26042227 | SIGNOR-279762 |
| TLK1 | MAPKAPK5 | Ser354 | VSLKPLHsVNNPILR | phosphorylation up-regulates activity | 35064619 | SIGNOR-276746 |
| MAPK6 | MAPKAPK5 | Thr182 | IDQGDLMtPQFTPYY | phosphorylation up-regulates activity | 20734105 | SIGNOR-279073 |
| MAPK14 | MAPKAPK5 | Thr182 | IDQGDLMtPQFTPYY | phosphorylation up-regulates activity | 9628874 | SIGNOR-58135 |
| MAPK1 | MAPKAPK5 | Thr182 | IDQGDLMtPQFTPYY | phosphorylation up-regulates | 21666810 | SIGNOR-174076 |
| Enzyme | Effect | Phosphosite | Effect | Target | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| MAPK11 | phosphorylation up-regulates → | MAPKAPK5 PThr182 | phosphorylation up-regulates → | MAPKAPK5 | 9628874 | SIGNOR-58131 |
| MAPK1 | phosphorylation up-regulates → | MAPKAPK5 PThr182 | phosphorylation up-regulates → | MAPKAPK5 | 9628874 | SIGNOR-58127 |
| MAPK4 | phosphorylation up-regulates → | MAPKAPK5 PThr182 | phosphorylation up-regulates → | MAPKAPK5 | 20734105 | SIGNOR-279072 |
| TLK1 | phosphorylation up-regulates → | MAPKAPK5 PSer386 | phosphorylation up-regulates → | MAPKAPK5 | 35064619 | SIGNOR-276747 |
| TLK1 | phosphorylation up-regulates → | MAPKAPK5 PSer160 | phosphorylation up-regulates → | MAPKAPK5 | 35064619 | SIGNOR-276745 |
| SRC | phosphorylation up-regulates → | MAPKAPK5 PTyr188 | phosphorylation up-regulates → | MAPKAPK5 | 26042227 | SIGNOR-279761 |
| SRC | phosphorylation up-regulates → | MAPKAPK5 PTyr216 | phosphorylation up-regulates → | MAPKAPK5 | 26042227 | SIGNOR-279762 |
| TLK1 | phosphorylation up-regulates → | MAPKAPK5 PSer354 | phosphorylation up-regulates → | MAPKAPK5 | 35064619 | SIGNOR-276746 |
| MAPK6 | phosphorylation up-regulates → | MAPKAPK5 PThr182 | phosphorylation up-regulates → | MAPKAPK5 | 20734105 | SIGNOR-279073 |
| MAPK14 | phosphorylation up-regulates → | MAPKAPK5 PThr182 | phosphorylation up-regulates → | MAPKAPK5 | 9628874 | SIGNOR-58135 |
| MAPK1 | phosphorylation up-regulates → | MAPKAPK5 PThr182 | phosphorylation up-regulates → | MAPKAPK5 | 21666810 | SIGNOR-174076 |
| Regulator | Mechanism/Effect | Target | SIGNOR-ID |
|---|---|---|---|
| MAPK11 | phosphorylation → up-regulates | MAPKAPK5 | SIGNOR-58131 |
| MAPK1 | phosphorylation → up-regulates | MAPKAPK5 | SIGNOR-58127 |
| MAPK4 | phosphorylation → up-regulates activity | MAPKAPK5 | SIGNOR-279072 |
| TLK1 | phosphorylation → up-regulates activity | MAPKAPK5 | SIGNOR-276747 |
| TLK1 | phosphorylation → up-regulates activity | MAPKAPK5 | SIGNOR-276745 |
| SRC | phosphorylation → up-regulates quantity | MAPKAPK5 | SIGNOR-279761 |
| SRC | phosphorylation → up-regulates quantity | MAPKAPK5 | SIGNOR-279762 |
| TLK1 | phosphorylation → up-regulates activity | MAPKAPK5 | SIGNOR-276746 |
| MAPK6 | phosphorylation → up-regulates activity | MAPKAPK5 | SIGNOR-279073 |
| MAPK14 | phosphorylation → up-regulates activity | MAPKAPK5 | SIGNOR-58135 |
| MAPK1 | phosphorylation → up-regulates | MAPKAPK5 | SIGNOR-174076 |