| Modifier | Substrate | Residue | Sequence | Mechanism/Effect | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| MAPK1 | MAPKAPK5 | Thr182 | IDQGDLMtPQFTPYY | phosphorylation up-regulates | 21666810 | SIGNOR-174076 |
| MAPK11 | MAPKAPK5 | Thr182 | IDQGDLMtPQFTPYY | phosphorylation up-regulates | 9628874 | SIGNOR-58131 |
| MAPK1 | MAPKAPK5 | Thr182 | IDQGDLMtPQFTPYY | phosphorylation up-regulates | 9628874 | SIGNOR-58127 |
| MAPK4 | MAPKAPK5 | Thr182 | IDQGDLMtPQFTPYY | phosphorylation up-regulates activity | 20734105 | SIGNOR-279072 |
| MAPK6 | MAPKAPK5 | Thr182 | IDQGDLMtPQFTPYY | phosphorylation up-regulates activity | 20734105 | SIGNOR-279073 |
| MAPK14 | MAPKAPK5 | Thr182 | IDQGDLMtPQFTPYY | phosphorylation up-regulates activity | 9628874 | SIGNOR-58135 |
| Enzyme | Effect | Phosphosite | Effect | Target | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| MAPK1 | phosphorylation up-regulates → | MAPKAPK5 PThr182 | phosphorylation up-regulates → | MAPKAPK5 | 21666810 | SIGNOR-174076 |
| MAPK11 | phosphorylation up-regulates → | MAPKAPK5 PThr182 | phosphorylation up-regulates → | MAPKAPK5 | 9628874 | SIGNOR-58131 |
| MAPK1 | phosphorylation up-regulates → | MAPKAPK5 PThr182 | phosphorylation up-regulates → | MAPKAPK5 | 9628874 | SIGNOR-58127 |
| MAPK4 | phosphorylation up-regulates → | MAPKAPK5 PThr182 | phosphorylation up-regulates → | MAPKAPK5 | 20734105 | SIGNOR-279072 |
| MAPK6 | phosphorylation up-regulates → | MAPKAPK5 PThr182 | phosphorylation up-regulates → | MAPKAPK5 | 20734105 | SIGNOR-279073 |
| MAPK14 | phosphorylation up-regulates → | MAPKAPK5 PThr182 | phosphorylation up-regulates → | MAPKAPK5 | 9628874 | SIGNOR-58135 |
| Regulator | Mechanism/Effect | Target | SIGNOR-ID |
|---|---|---|---|
| MAPK1 | phosphorylation → up-regulates | MAPKAPK5 | SIGNOR-174076 |
| MAPK11 | phosphorylation → up-regulates | MAPKAPK5 | SIGNOR-58131 |
| MAPK1 | phosphorylation → up-regulates | MAPKAPK5 | SIGNOR-58127 |
| MAPK4 | phosphorylation → up-regulates activity | MAPKAPK5 | SIGNOR-279072 |
| MAPK6 | phosphorylation → up-regulates activity | MAPKAPK5 | SIGNOR-279073 |
| MAPK14 | phosphorylation → up-regulates activity | MAPKAPK5 | SIGNOR-58135 |
