| Name | MFN1 |
| ID | Q8IWA4 |
| Role | substrate |
| Enzymatic Domains |
Dynamin-type G 72-321 PROSITE-ProRule |
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| Modifier | Substrate | Residue | Sequence | Mechanism/Effect | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| PRKCB | MFN1 | Ser86 | AFFGRTSsGKSSVIN | phosphorylation down-regulates activity | 30659190 | SIGNOR-273826 |
| ERK1/2 | MFN1 | Thr562 | LPRSLASTPTAPTTP | phosphorylation up-regulates activity | 25801171 | SIGNOR-274134 |
| Enzyme | Effect | Phosphosite | Effect | Target | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| PRKCB | phosphorylation up-regulates → | MFN1 PSer86 | phosphorylation down-regulates ⊣ | MFN1 | 30659190 | SIGNOR-273826 |
| ERK1/2 | phosphorylation up-regulates → | MFN1 PThr562 | phosphorylation up-regulates → | MFN1 | 25801171 | SIGNOR-274134 |
| Regulator | Mechanism/Effect | Target | SIGNOR-ID |
|---|---|---|---|
| PRKCB | phosphorylation → down-regulates activity | MFN1 | SIGNOR-273826 |
| ERK1/2 | phosphorylation → up-regulates activity | MFN1 | SIGNOR-274134 |