| Modifier | Substrate | Residue | Sequence | Mechanism/Effect | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| LCK | LAX1 | Tyr268 | SSQISNDyVNMTGLD | phosphorylation up-regulates activity | 12359715 | SIGNOR-273526 |
| SYK | LAX1 | Tyr294 | AFQCCRDyENVPAAD | phosphorylation up-regulates activity | 12359715 | SIGNOR-273534 |
| SYK | LAX1 | Tyr193 | SSEDSHDyVNVPTAE | phosphorylation up-regulates activity | 12359715 | SIGNOR-273532 |
| LCK | LAX1 | Tyr193 | SSEDSHDyVNVPTAE | phosphorylation up-regulates activity | 12359715 | SIGNOR-273525 |
| SYK | LAX1 | Tyr373 | SNEDSSDyENVLTAK | phosphorylation up-regulates activity | 12359715 | SIGNOR-273535 |
| SYK | LAX1 | Tyr268 | SSQISNDyVNMTGLD | phosphorylation up-regulates activity | 12359715 | SIGNOR-273533 |
| LCK | LAX1 | Tyr294 | AFQCCRDyENVPAAD | phosphorylation up-regulates activity | 12359715 | SIGNOR-273527 |
| LCK | LAX1 | Tyr373 | SNEDSSDyENVLTAK | phosphorylation up-regulates activity | 12359715 | SIGNOR-273528 |
| Enzyme | Effect | Phosphosite | Effect | Target | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| LCK | phosphorylation up-regulates → | LAX1 PTyr268 | phosphorylation up-regulates → | LAX1 | 12359715 | SIGNOR-273526 |
| SYK | phosphorylation up-regulates → | LAX1 PTyr294 | phosphorylation up-regulates → | LAX1 | 12359715 | SIGNOR-273534 |
| SYK | phosphorylation up-regulates → | LAX1 PTyr193 | phosphorylation up-regulates → | LAX1 | 12359715 | SIGNOR-273532 |
| LCK | phosphorylation up-regulates → | LAX1 PTyr193 | phosphorylation up-regulates → | LAX1 | 12359715 | SIGNOR-273525 |
| SYK | phosphorylation up-regulates → | LAX1 PTyr373 | phosphorylation up-regulates → | LAX1 | 12359715 | SIGNOR-273535 |
| SYK | phosphorylation up-regulates → | LAX1 PTyr268 | phosphorylation up-regulates → | LAX1 | 12359715 | SIGNOR-273533 |
| LCK | phosphorylation up-regulates → | LAX1 PTyr294 | phosphorylation up-regulates → | LAX1 | 12359715 | SIGNOR-273527 |
| LCK | phosphorylation up-regulates → | LAX1 PTyr373 | phosphorylation up-regulates → | LAX1 | 12359715 | SIGNOR-273528 |
| Regulator | Mechanism/Effect | Target | SIGNOR-ID |
|---|---|---|---|
| LCK | phosphorylation → up-regulates activity | LAX1 | SIGNOR-273526 |
| SYK | phosphorylation → up-regulates activity | LAX1 | SIGNOR-273534 |
| SYK | phosphorylation → up-regulates activity | LAX1 | SIGNOR-273532 |
| LCK | phosphorylation → up-regulates activity | LAX1 | SIGNOR-273525 |
| SYK | phosphorylation → up-regulates activity | LAX1 | SIGNOR-273535 |
| SYK | phosphorylation → up-regulates activity | LAX1 | SIGNOR-273533 |
| LCK | phosphorylation → up-regulates activity | LAX1 | SIGNOR-273527 |
| LCK | phosphorylation → up-regulates activity | LAX1 | SIGNOR-273528 |
