| Modifier | Substrate | Residue | Sequence | Mechanism/Effect | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| CDK1 | SIRT2 | Ser368 | PNPSTSAsPKKSPPP | phosphorylation down-regulates | 17488717 | SIGNOR-154681 |
| CDK2 | SIRT2 | Ser368 | PNPSTSAsPKKSPPP | phosphorylation down-regulates | 18332217 | SIGNOR-177972 |
| CDK5 | SIRT2 | Ser368 | PNPSTSAsPKKSPPP | phosphorylation up-regulates activity | 35443760 | SIGNOR-279684 |
| CDC14B | SIRT2 | Ser368 | PNPSTSAsPKKSPPP | dephosphorylation unknown | 17488717 | SIGNOR-248338 |
| CyclinE/CDK2 | SIRT2 | Ser368 | PNPSTSAsPKKSPPP | phosphorylation down-regulates | 18332217 | SIGNOR-216725 |
| CDC14A | SIRT2 | Ser368 | PNPSTSAsPKKSPPP | dephosphorylation unknown | 17488717 | SIGNOR-248834 |
| Enzyme | Effect | Phosphosite | Effect | Target | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| CDK1 | phosphorylation up-regulates → | SIRT2 PSer368 | phosphorylation down-regulates ⊣ | SIRT2 | 17488717 | SIGNOR-154681 |
| CDK2 | phosphorylation up-regulates → | SIRT2 PSer368 | phosphorylation down-regulates ⊣ | SIRT2 | 18332217 | SIGNOR-177972 |
| CDK5 | phosphorylation up-regulates → | SIRT2 PSer368 | phosphorylation up-regulates → | SIRT2 | 35443760 | SIGNOR-279684 |
| CDC14B | dephosphorylation down-regulates ⊣ | SIRT2 PSer368 | dephosphorylation up-regulates → | SIRT2 | 17488717 | SIGNOR-248338 |
| CyclinE/CDK2 | phosphorylation up-regulates → | SIRT2 PSer368 | phosphorylation down-regulates ⊣ | SIRT2 | 18332217 | SIGNOR-216725 |
| CDC14A | dephosphorylation down-regulates ⊣ | SIRT2 PSer368 | dephosphorylation up-regulates → | SIRT2 | 17488717 | SIGNOR-248834 |
| Regulator | Mechanism/Effect | Target | SIGNOR-ID |
|---|---|---|---|
| CDK1 | phosphorylation down-regulates | SIRT2 | SIGNOR-154681 |
| CDK2 | phosphorylation down-regulates | SIRT2 | SIGNOR-177972 |
| CDK5 | phosphorylation → up-regulates activity | SIRT2 | SIGNOR-279684 |
| CDC14B | dephosphorylation → unknown | SIRT2 | SIGNOR-248338 |
| CyclinE/CDK2 | phosphorylation down-regulates | SIRT2 | SIGNOR-216725 |
| CDC14A | dephosphorylation → unknown | SIRT2 | SIGNOR-248834 |
