| Modifier | Substrate | Residue | Sequence | Mechanism/Effect | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| FAM20C | VWF | – | phosphorylation up-regulates activity | 30864273 | SIGNOR-279331 | |
| FAM20C | P4HB | Ser357 | KIKPHLMsQELPEDW | phosphorylation up-regulates activity | 32149426 | SIGNOR-275574 |
| FAM20C | SPP1 | – | phosphorylation down-regulates quantity | 34433585 | SIGNOR-278936 | |
| FAM20C | HRC | Ser96 | EKEDEDVsKEYGHLL | phosphorylation up-regulates activity | 28784772 | SIGNOR-273639 |
| FAM20C | DMP1 | – | phosphorylation up-regulates quantity | 25026495 | SIGNOR-280011 | |
| FAM20C | STIM1 | Ser88 | GDVDVEEsDEFLRED | phosphorylation up-regulates activity | 30520731 | SIGNOR-279173 |
| FAM20C | SLC35G1 | – | phosphorylation up-regulates activity | 30520731 | SIGNOR-280012 | |
| FAM20C | PCSK9 | Ser47 | ELVLALRsEEDGLAE | phosphorylation up-regulates activity | 31553664 | SIGNOR-278935 |
| FAM20C | ERO1A | Ser145 | GAVDESLsEETQKAV | phosphorylation up-regulates activity | 29858230 | SIGNOR-277395 |
| FAM20C | SDF4 | – | phosphorylation up-regulates activity | 32422653 | SIGNOR-279330 | |
| FAM20C | FGF23 | Ser180 | IPRRHTRsAEDDSER | phosphorylation down-regulates activity | 24706917 | SIGNOR-260925 |
| FAM20C | AMBN | – | phosphorylation up-regulates activity | 25789606 | SIGNOR-280010 |
| Enzyme | Effect | Phosphosite | Effect | Target | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| FAM20C | phosphorylation up-regulates → | P4HB PSer357 | phosphorylation up-regulates → | P4HB | 32149426 | SIGNOR-275574 |
| FAM20C | phosphorylation up-regulates → | HRC PSer96 | phosphorylation up-regulates → | HRC | 28784772 | SIGNOR-273639 |
| FAM20C | phosphorylation up-regulates → | STIM1 PSer88 | phosphorylation up-regulates → | STIM1 | 30520731 | SIGNOR-279173 |
| FAM20C | phosphorylation up-regulates → | PCSK9 PSer47 | phosphorylation up-regulates → | PCSK9 | 31553664 | SIGNOR-278935 |
| FAM20C | phosphorylation up-regulates → | ERO1A PSer145 | phosphorylation up-regulates → | ERO1A | 29858230 | SIGNOR-277395 |
| FAM20C | phosphorylation up-regulates → | FGF23 PSer180 | phosphorylation down-regulates ⊣ | FGF23 | 24706917 | SIGNOR-260925 |
| Regulator | Mechanism/Effect | Target | SIGNOR-ID |
|---|---|---|---|
| FAM20C | phosphorylation → up-regulates activity | VWF | SIGNOR-279331 |
| FAM20C | phosphorylation → up-regulates activity | P4HB | SIGNOR-275574 |
| FAM20C | phosphorylation → down-regulates quantity | SPP1 | SIGNOR-278936 |
| FAM20C | phosphorylation → up-regulates activity | HRC | SIGNOR-273639 |
| FAM20C | phosphorylation → up-regulates quantity | DMP1 | SIGNOR-280011 |
| FAM20C | phosphorylation → up-regulates activity | STIM1 | SIGNOR-279173 |
| FAM20C | phosphorylation → up-regulates activity | SLC35G1 | SIGNOR-280012 |
| FAM20C | phosphorylation → up-regulates activity | PCSK9 | SIGNOR-278935 |
| FAM20C | phosphorylation → up-regulates activity | ERO1A | SIGNOR-277395 |
| FAM20C | phosphorylation → up-regulates activity | SDF4 | SIGNOR-279330 |
| FAM20C | phosphorylation → down-regulates activity | FGF23 | SIGNOR-260925 |
| FAM20C | phosphorylation → up-regulates activity | AMBN | SIGNOR-280010 |
