| Modifier | Substrate | Residue | Sequence | Mechanism/Effect | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| RPAP2 | POLR2A | Ser1616 | TPQSPSYsPTSPSYS | dephosphorylation up-regulates activity | 22137580 | SIGNOR-248734 |
| RPAP2 | POLR2A | Ser1619 | SPSYSPTsPSYSPTS | dephosphorylation up-regulates activity | 22137580 | SIGNOR-248735 |
| RPAP2 | POLR2A | Ser1623 | SPTSPSYsPTSPSYS | dephosphorylation up-regulates activity | 22137580 | SIGNOR-248747 |
| RPAP2 | POLR2A | Ser1626 | SPSYSPTsPSYSPTS | dephosphorylation up-regulates activity | 22137580 | SIGNOR-248736 |
| RPAP2 | POLR2A | Ser1644 | SPTSPSYsPTSPSYS | dephosphorylation up-regulates activity | 22137580 | SIGNOR-248748 |
| RPAP2 | POLR2A | Ser1647 | SPSYSPTsPSYSPTS | dephosphorylation up-regulates activity | 22137580 | SIGNOR-248737 |
| RPAP2 | POLR2A | Ser1651 | SPTSPSYsPTSPSYS | dephosphorylation up-regulates activity | 22137580 | SIGNOR-248749 |
| RPAP2 | POLR2A | Ser1654 | SPSYSPTsPSYSPTS | dephosphorylation up-regulates activity | 22137580 | SIGNOR-248738 |
| RPAP2 | POLR2A | Ser1665 | SPTSPSYsPTSPSYS | dephosphorylation up-regulates activity | 22137580 | SIGNOR-248750 |
| RPAP2 | POLR2A | Ser1668 | SPSYSPTsPSYSPTS | dephosphorylation up-regulates activity | 22137580 | SIGNOR-248739 |
| RPAP2 | POLR2A | Ser1672 | SPTSPSYsPTSPSYS | dephosphorylation up-regulates activity | 22137580 | SIGNOR-248751 |
| RPAP2 | POLR2A | Ser1675 | SPSYSPTsPSYSPTS | dephosphorylation up-regulates activity | 22137580 | SIGNOR-248740 |
| RPAP2 | POLR2A | Ser1693 | SPTSPSYsPTSPSYS | dephosphorylation up-regulates activity | 22137580 | SIGNOR-248752 |
| RPAP2 | POLR2A | Ser1696 | SPSYSPTsPSYSPTS | dephosphorylation up-regulates activity | 22137580 | SIGNOR-248741 |
| RPAP2 | POLR2A | Ser1714 | SPTSPSYsPTSPSYS | dephosphorylation up-regulates activity | 22137580 | SIGNOR-248753 |
| RPAP2 | POLR2A | Ser1717 | SPSYSPTsPSYSPTS | dephosphorylation up-regulates activity | 22137580 | SIGNOR-248742 |
| RPAP2 | POLR2A | Ser1721 | SPTSPSYsPTSPSYS | dephosphorylation up-regulates activity | 22137580 | SIGNOR-248754 |
| RPAP2 | POLR2A | Ser1724 | SPSYSPTsPSYSPTS | dephosphorylation up-regulates activity | 22137580 | SIGNOR-248743 |
| RPAP2 | POLR2A | Ser1735 | SPTSPSYsPTSPSYS | dephosphorylation up-regulates activity | 22137580 | SIGNOR-248755 |
| RPAP2 | POLR2A | Ser1738 | SPSYSPTsPSYSPTS | dephosphorylation up-regulates activity | 22137580 | SIGNOR-248744 |
| RPAP2 | POLR2A | Ser1763 | TPTSPSYsPTSPSYS | dephosphorylation up-regulates activity | 22137580 | SIGNOR-248756 |
| RPAP2 | POLR2A | Ser1766 | SPSYSPTsPSYSPTS | dephosphorylation up-regulates activity | 22137580 | SIGNOR-248745 |
| RPAP2 | POLR2A | Ser1784 | TPTSPNYsPTSPSYS | dephosphorylation up-regulates activity | 22137580 | SIGNOR-248757 |
| RPAP2 | POLR2A | Ser1787 | SPNYSPTsPSYSPTS | dephosphorylation up-regulates activity | 22137580 | SIGNOR-248746 |
| Enzyme | Effect | Phosphosite | Effect | Target | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| RPAP2 | dephosphorylation down-regulates ⊣ | POLR2A PSer1616 | dephosphorylation down-regulates ⊣ | POLR2A | 22137580 | SIGNOR-248734 |
| RPAP2 | dephosphorylation down-regulates ⊣ | POLR2A PSer1619 | dephosphorylation down-regulates ⊣ | POLR2A | 22137580 | SIGNOR-248735 |
| RPAP2 | dephosphorylation down-regulates ⊣ | POLR2A PSer1623 | dephosphorylation down-regulates ⊣ | POLR2A | 22137580 | SIGNOR-248747 |
| RPAP2 | dephosphorylation down-regulates ⊣ | POLR2A PSer1626 | dephosphorylation down-regulates ⊣ | POLR2A | 22137580 | SIGNOR-248736 |
| RPAP2 | dephosphorylation down-regulates ⊣ | POLR2A PSer1644 | dephosphorylation down-regulates ⊣ | POLR2A | 22137580 | SIGNOR-248748 |
| RPAP2 | dephosphorylation down-regulates ⊣ | POLR2A PSer1647 | dephosphorylation down-regulates ⊣ | POLR2A | 22137580 | SIGNOR-248737 |
| RPAP2 | dephosphorylation down-regulates ⊣ | POLR2A PSer1651 | dephosphorylation down-regulates ⊣ | POLR2A | 22137580 | SIGNOR-248749 |
| RPAP2 | dephosphorylation down-regulates ⊣ | POLR2A PSer1654 | dephosphorylation down-regulates ⊣ | POLR2A | 22137580 | SIGNOR-248738 |
| RPAP2 | dephosphorylation down-regulates ⊣ | POLR2A PSer1665 | dephosphorylation down-regulates ⊣ | POLR2A | 22137580 | SIGNOR-248750 |
| RPAP2 | dephosphorylation down-regulates ⊣ | POLR2A PSer1668 | dephosphorylation down-regulates ⊣ | POLR2A | 22137580 | SIGNOR-248739 |
| RPAP2 | dephosphorylation down-regulates ⊣ | POLR2A PSer1672 | dephosphorylation down-regulates ⊣ | POLR2A | 22137580 | SIGNOR-248751 |
| RPAP2 | dephosphorylation down-regulates ⊣ | POLR2A PSer1675 | dephosphorylation down-regulates ⊣ | POLR2A | 22137580 | SIGNOR-248740 |
| RPAP2 | dephosphorylation down-regulates ⊣ | POLR2A PSer1693 | dephosphorylation down-regulates ⊣ | POLR2A | 22137580 | SIGNOR-248752 |
| RPAP2 | dephosphorylation down-regulates ⊣ | POLR2A PSer1696 | dephosphorylation down-regulates ⊣ | POLR2A | 22137580 | SIGNOR-248741 |
| RPAP2 | dephosphorylation down-regulates ⊣ | POLR2A PSer1714 | dephosphorylation down-regulates ⊣ | POLR2A | 22137580 | SIGNOR-248753 |
| RPAP2 | dephosphorylation down-regulates ⊣ | POLR2A PSer1717 | dephosphorylation down-regulates ⊣ | POLR2A | 22137580 | SIGNOR-248742 |
| RPAP2 | dephosphorylation down-regulates ⊣ | POLR2A PSer1721 | dephosphorylation down-regulates ⊣ | POLR2A | 22137580 | SIGNOR-248754 |
| RPAP2 | dephosphorylation down-regulates ⊣ | POLR2A PSer1724 | dephosphorylation down-regulates ⊣ | POLR2A | 22137580 | SIGNOR-248743 |
| RPAP2 | dephosphorylation down-regulates ⊣ | POLR2A PSer1735 | dephosphorylation down-regulates ⊣ | POLR2A | 22137580 | SIGNOR-248755 |
| RPAP2 | dephosphorylation down-regulates ⊣ | POLR2A PSer1738 | dephosphorylation down-regulates ⊣ | POLR2A | 22137580 | SIGNOR-248744 |
| RPAP2 | dephosphorylation down-regulates ⊣ | POLR2A PSer1763 | dephosphorylation down-regulates ⊣ | POLR2A | 22137580 | SIGNOR-248756 |
| RPAP2 | dephosphorylation down-regulates ⊣ | POLR2A PSer1766 | dephosphorylation down-regulates ⊣ | POLR2A | 22137580 | SIGNOR-248745 |
| RPAP2 | dephosphorylation down-regulates ⊣ | POLR2A PSer1784 | dephosphorylation down-regulates ⊣ | POLR2A | 22137580 | SIGNOR-248757 |
| RPAP2 | dephosphorylation down-regulates ⊣ | POLR2A PSer1787 | dephosphorylation down-regulates ⊣ | POLR2A | 22137580 | SIGNOR-248746 |
| Regulator | Mechanism/Effect | Target | SIGNOR-ID |
|---|---|---|---|
| RPAP2 | dephosphorylation → up-regulates activity | POLR2A | SIGNOR-248734 |
| RPAP2 | dephosphorylation → up-regulates activity | POLR2A | SIGNOR-248735 |
| RPAP2 | dephosphorylation → up-regulates activity | POLR2A | SIGNOR-248747 |
| RPAP2 | dephosphorylation → up-regulates activity | POLR2A | SIGNOR-248736 |
| RPAP2 | dephosphorylation → up-regulates activity | POLR2A | SIGNOR-248748 |
| RPAP2 | dephosphorylation → up-regulates activity | POLR2A | SIGNOR-248737 |
| RPAP2 | dephosphorylation → up-regulates activity | POLR2A | SIGNOR-248749 |
| RPAP2 | dephosphorylation → up-regulates activity | POLR2A | SIGNOR-248738 |
| RPAP2 | dephosphorylation → up-regulates activity | POLR2A | SIGNOR-248750 |
| RPAP2 | dephosphorylation → up-regulates activity | POLR2A | SIGNOR-248739 |
| RPAP2 | dephosphorylation → up-regulates activity | POLR2A | SIGNOR-248751 |
| RPAP2 | dephosphorylation → up-regulates activity | POLR2A | SIGNOR-248740 |
| RPAP2 | dephosphorylation → up-regulates activity | POLR2A | SIGNOR-248752 |
| RPAP2 | dephosphorylation → up-regulates activity | POLR2A | SIGNOR-248741 |
| RPAP2 | dephosphorylation → up-regulates activity | POLR2A | SIGNOR-248753 |
| RPAP2 | dephosphorylation → up-regulates activity | POLR2A | SIGNOR-248742 |
| RPAP2 | dephosphorylation → up-regulates activity | POLR2A | SIGNOR-248754 |
| RPAP2 | dephosphorylation → up-regulates activity | POLR2A | SIGNOR-248743 |
| RPAP2 | dephosphorylation → up-regulates activity | POLR2A | SIGNOR-248755 |
| RPAP2 | dephosphorylation → up-regulates activity | POLR2A | SIGNOR-248744 |
| RPAP2 | dephosphorylation → up-regulates activity | POLR2A | SIGNOR-248756 |
| RPAP2 | dephosphorylation → up-regulates activity | POLR2A | SIGNOR-248745 |
| RPAP2 | dephosphorylation → up-regulates activity | POLR2A | SIGNOR-248757 |
| RPAP2 | dephosphorylation → up-regulates activity | POLR2A | SIGNOR-248746 |
