Modifier	Substrate	Residue	Sequence	Mechanism/Effect	PMID	Interaction ID
ULK2	DENND3	Ser472	THRRMVVsMPNLQDI	phosphorylation up-regulates activity	25925668	SIGNOR-264732
ULK2	DENND3	Ser490	ELAPRNSsLRLTDTA	phosphorylation up-regulates activity	25925668	SIGNOR-264733
ULK2	ATG13	–		phosphorylation up-regulates	19225151	SIGNOR-184126
ULK2	ENO1	Ser115	ANAILGVsLAVCKAG	phosphorylation down-regulates activity	27153534	SIGNOR-274038
ULK2	ENO1	Ser282	QLADLYKsFIKDYPV	phosphorylation down-regulates activity	27153534	SIGNOR-274037
ULK2	PFKM	Ser74	EATWESVsMMLQLGG	phosphorylation down-regulates activity	27153534	SIGNOR-274043
ULK2	PFKM	Ser762	YEIDLDTsDHAHLEH	phosphorylation down-regulates activity	27153534	SIGNOR-274044
ULK2	FBP1	Ser63	HLYGIAGsTNVTGDQ	phosphorylation down-regulates activity	27153534	SIGNOR-274040
ULK2	FBP1	Ser88	LVMNMLKsSFATCVL	phosphorylation down-regulates activity	27153534	SIGNOR-274039
ULK2	HK1	Ser124	NIVHGSGsQLFDHVA	phosphorylation up-regulates activity	27153534	SIGNOR-274042
ULK2	HK1	Ser364	TRLGVEPsDDDCVSV	phosphorylation up-regulates activity	27153534	SIGNOR-274041
ULK2	PRKAA2	–		phosphorylation down-regulates	21460634	SIGNOR-173089
ULK2	RB1CC1	–		phosphorylation up-regulates activity	33135781	SIGNOR-280159
ULK2	PRKAG3	–		phosphorylation down-regulates	21460634	SIGNOR-173095
ULK2	PRKAB1	–		phosphorylation down-regulates	21460634	SIGNOR-173092
ULK2	AMPK	–		phosphorylation down-regulates	21460634	SIGNOR-217487

Enzyme	Effect	Phosphosite	Effect	Target	PMID	Interaction ID
ULK2	phosphorylation up-regulates →	DENND3 PSer472	phosphorylation up-regulates →	DENND3	25925668	SIGNOR-264732
ULK2	phosphorylation up-regulates →	DENND3 PSer490	phosphorylation up-regulates →	DENND3	25925668	SIGNOR-264733
ULK2	phosphorylation up-regulates →	ENO1 PSer115	phosphorylation down-regulates ⊣	ENO1	27153534	SIGNOR-274038
ULK2	phosphorylation up-regulates →	ENO1 PSer282	phosphorylation down-regulates ⊣	ENO1	27153534	SIGNOR-274037
ULK2	phosphorylation up-regulates →	PFKM PSer74	phosphorylation down-regulates ⊣	PFKM	27153534	SIGNOR-274043
ULK2	phosphorylation up-regulates →	PFKM PSer762	phosphorylation down-regulates ⊣	PFKM	27153534	SIGNOR-274044
ULK2	phosphorylation up-regulates →	FBP1 PSer63	phosphorylation down-regulates ⊣	FBP1	27153534	SIGNOR-274040
ULK2	phosphorylation up-regulates →	FBP1 PSer88	phosphorylation down-regulates ⊣	FBP1	27153534	SIGNOR-274039
ULK2	phosphorylation up-regulates →	HK1 PSer124	phosphorylation up-regulates →	HK1	27153534	SIGNOR-274042
ULK2	phosphorylation up-regulates →	HK1 PSer364	phosphorylation up-regulates →	HK1	27153534	SIGNOR-274041

Regulator	Mechanism/Effect	Target	SIGNOR-ID
ULK2	phosphorylation → up-regulates activity	DENND3	SIGNOR-264732
ULK2	phosphorylation → up-regulates activity	DENND3	SIGNOR-264733
ULK2	phosphorylation → up-regulates	ATG13	SIGNOR-184126
ULK2	phosphorylation → down-regulates activity	ENO1	SIGNOR-274038
ULK2	phosphorylation → down-regulates activity	ENO1	SIGNOR-274037
ULK2	phosphorylation → down-regulates activity	PFKM	SIGNOR-274043
ULK2	phosphorylation → down-regulates activity	PFKM	SIGNOR-274044
ULK2	phosphorylation → down-regulates activity	FBP1	SIGNOR-274040
ULK2	phosphorylation → down-regulates activity	FBP1	SIGNOR-274039
ULK2	phosphorylation → up-regulates activity	HK1	SIGNOR-274042
ULK2	phosphorylation → up-regulates activity	HK1	SIGNOR-274041
ULK2	phosphorylation down-regulates	PRKAA2	SIGNOR-173089
ULK2	phosphorylation → up-regulates activity	RB1CC1	SIGNOR-280159
ULK2	phosphorylation down-regulates	PRKAG3	SIGNOR-173095
ULK2	phosphorylation down-regulates	PRKAB1	SIGNOR-173092
ULK2	phosphorylation down-regulates	AMPK	SIGNOR-217487