| Name | ABI1 |
| ID | Q8IZP0 |
| Role | substrate |
| Enzymatic Domains |
t-SNARE coiled-coil homology 45-107 PROSITE-ProRule
SH3 446-505 PROSITE-ProRule |
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| Modifier | Substrate | Residue | Sequence | Mechanism/Effect | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| CyclinB/CDK1 | ABI1 | Ser216 | VPNDYMTsPARLGSQ | phosphorylation down-regulates activity | 21900237 | SIGNOR-264452 |
| MAPK1 | ABI1 | Ser222 | TSPARLGsQHSPGRT | phosphorylation up-regulates | 21419341 | SIGNOR-172873 |
| ERK1/2 | ABI1 | – | phosphorylation up-regulates | 21419341 | SIGNOR-270161 | |
| PTEN | ABI1 | Tyr213 | PPTVPNDyMTSPARL | dephosphorylation down-regulates quantity by destabilization | 32673396 | SIGNOR-276948 |
| MAPK1 | ABI1 | Ser225 | ARLGSQHsPGRTASL | phosphorylation up-regulates | 21419341 | SIGNOR-172877 |
| PTEN | ABI1 | Ser216 | VPNDYMTsPARLGSQ | dephosphorylation down-regulates quantity by destabilization | 32673396 | SIGNOR-276949 |
| MAPK3 | ABI1 | Ser225 | ARLGSQHsPGRTASL | phosphorylation up-regulates | 21419341 | SIGNOR-172881 |
| CDK1 | ABI1 | Ser216 | VPNDYMTsPARLGSQ | phosphorylation down-regulates activity | 21900237 | SIGNOR-264421 |
| MAPK1 | ABI1 | Ser183 | PPTQKPPsPPMSGRG | phosphorylation up-regulates | 21419341 | SIGNOR-172869 |
| ABL1 | ABI1 | Tyr213 | PPTVPNDyMTSPARL | phosphorylation up-regulates | 21320496 | SIGNOR-172017 |
| Gbeta | ABI1 | – | phosphorylation up-regulates | 21419341 | SIGNOR-270048 |
| Enzyme | Effect | Phosphosite | Effect | Target | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| CyclinB/CDK1 | phosphorylation up-regulates → | ABI1 PSer216 | phosphorylation down-regulates ⊣ | ABI1 | 21900237 | SIGNOR-264452 |
| MAPK1 | phosphorylation up-regulates → | ABI1 PSer222 | phosphorylation up-regulates → | ABI1 | 21419341 | SIGNOR-172873 |
| PTEN | dephosphorylation down-regulates ⊣ | ABI1 PTyr213 | dephosphorylation up-regulates → | ABI1 | 32673396 | SIGNOR-276948 |
| MAPK1 | phosphorylation up-regulates → | ABI1 PSer225 | phosphorylation up-regulates → | ABI1 | 21419341 | SIGNOR-172877 |
| PTEN | dephosphorylation down-regulates ⊣ | ABI1 PSer216 | dephosphorylation up-regulates → | ABI1 | 32673396 | SIGNOR-276949 |
| MAPK3 | phosphorylation up-regulates → | ABI1 PSer225 | phosphorylation up-regulates → | ABI1 | 21419341 | SIGNOR-172881 |
| CDK1 | phosphorylation up-regulates → | ABI1 PSer216 | phosphorylation down-regulates ⊣ | ABI1 | 21900237 | SIGNOR-264421 |
| MAPK1 | phosphorylation up-regulates → | ABI1 PSer183 | phosphorylation up-regulates → | ABI1 | 21419341 | SIGNOR-172869 |
| ABL1 | phosphorylation up-regulates → | ABI1 PTyr213 | phosphorylation up-regulates → | ABI1 | 21320496 | SIGNOR-172017 |
| Regulator | Mechanism/Effect | Target | SIGNOR-ID |
|---|---|---|---|
| CyclinB/CDK1 | phosphorylation → down-regulates activity | ABI1 | SIGNOR-264452 |
| MAPK1 | phosphorylation → up-regulates | ABI1 | SIGNOR-172873 |
| ERK1/2 | phosphorylation → up-regulates | ABI1 | SIGNOR-270161 |
| PTEN | dephosphorylation down-regulates quantity by destabilization | ABI1 | SIGNOR-276948 |
| MAPK1 | phosphorylation → up-regulates | ABI1 | SIGNOR-172877 |
| PTEN | dephosphorylation down-regulates quantity by destabilization | ABI1 | SIGNOR-276949 |
| MAPK3 | phosphorylation → up-regulates | ABI1 | SIGNOR-172881 |
| CDK1 | phosphorylation → down-regulates activity | ABI1 | SIGNOR-264421 |
| MAPK1 | phosphorylation → up-regulates | ABI1 | SIGNOR-172869 |
| ABL1 | phosphorylation → up-regulates | ABI1 | SIGNOR-172017 |
| Gbeta | phosphorylation → up-regulates | ABI1 | SIGNOR-270048 |