| Modifier | Substrate | Residue | Sequence | Mechanism/Effect | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| SYK | GCSAM | Tyr106 | SGNSAEEyYENVPCK | phosphorylation up-regulates activity | 31362927 | SIGNOR-273570 |
| SYK | GCSAM | Tyr80 | QDNVDQTySEELCYT | phosphorylation up-regulates activity | 31362927 | SIGNOR-273572 |
| LYN | GCSAM | Tyr106 | SGNSAEEyYENVPCK | phosphorylation up-regulates activity | 31362927 | SIGNOR-273556 |
| SYK | GCSAM | Tyr107 | GNSAEEYyENVPCKA | phosphorylation up-regulates activity | 31362927 | SIGNOR-273571 |
| LYN | GCSAM | Tyr107 | GNSAEEYyENVPCKA | phosphorylation up-regulates activity | 31362927 | SIGNOR-273557 |
| SYK | GCSAM | Tyr128 | LGGTETEySLLHMPS | phosphorylation up-regulates activity | 31362927 | SIGNOR-273573 |
| LYN | GCSAM | Tyr80 | QDNVDQTySEELCYT | phosphorylation up-regulates activity | 31362927 | SIGNOR-273558 |
| LYN | GCSAM | Tyr128 | LGGTETEySLLHMPS | phosphorylation up-regulates activity | 31362927 | SIGNOR-273559 |
| LYN | GCSAM | Tyr86 | TYSEELCyTLINHRV | phosphorylation up-regulates activity | 31362927 | SIGNOR-273560 |
| SYK | GCSAM | Tyr86 | TYSEELCyTLINHRV | phosphorylation up-regulates activity | 31362927 | SIGNOR-273574 |
| Enzyme | Effect | Phosphosite | Effect | Target | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| SYK | phosphorylation up-regulates → | GCSAM PTyr106 | phosphorylation up-regulates → | GCSAM | 31362927 | SIGNOR-273570 |
| SYK | phosphorylation up-regulates → | GCSAM PTyr80 | phosphorylation up-regulates → | GCSAM | 31362927 | SIGNOR-273572 |
| LYN | phosphorylation up-regulates → | GCSAM PTyr106 | phosphorylation up-regulates → | GCSAM | 31362927 | SIGNOR-273556 |
| SYK | phosphorylation up-regulates → | GCSAM PTyr107 | phosphorylation up-regulates → | GCSAM | 31362927 | SIGNOR-273571 |
| LYN | phosphorylation up-regulates → | GCSAM PTyr107 | phosphorylation up-regulates → | GCSAM | 31362927 | SIGNOR-273557 |
| SYK | phosphorylation up-regulates → | GCSAM PTyr128 | phosphorylation up-regulates → | GCSAM | 31362927 | SIGNOR-273573 |
| LYN | phosphorylation up-regulates → | GCSAM PTyr80 | phosphorylation up-regulates → | GCSAM | 31362927 | SIGNOR-273558 |
| LYN | phosphorylation up-regulates → | GCSAM PTyr128 | phosphorylation up-regulates → | GCSAM | 31362927 | SIGNOR-273559 |
| LYN | phosphorylation up-regulates → | GCSAM PTyr86 | phosphorylation up-regulates → | GCSAM | 31362927 | SIGNOR-273560 |
| SYK | phosphorylation up-regulates → | GCSAM PTyr86 | phosphorylation up-regulates → | GCSAM | 31362927 | SIGNOR-273574 |
| Regulator | Mechanism/Effect | Target | SIGNOR-ID |
|---|---|---|---|
| SYK | phosphorylation → up-regulates activity | GCSAM | SIGNOR-273570 |
| SYK | phosphorylation → up-regulates activity | GCSAM | SIGNOR-273572 |
| LYN | phosphorylation → up-regulates activity | GCSAM | SIGNOR-273556 |
| SYK | phosphorylation → up-regulates activity | GCSAM | SIGNOR-273571 |
| LYN | phosphorylation → up-regulates activity | GCSAM | SIGNOR-273557 |
| SYK | phosphorylation → up-regulates activity | GCSAM | SIGNOR-273573 |
| LYN | phosphorylation → up-regulates activity | GCSAM | SIGNOR-273558 |
| LYN | phosphorylation → up-regulates activity | GCSAM | SIGNOR-273559 |
| LYN | phosphorylation → up-regulates activity | GCSAM | SIGNOR-273560 |
| SYK | phosphorylation → up-regulates activity | GCSAM | SIGNOR-273574 |
