| Modifier | Substrate | Residue | Sequence | Mechanism/Effect | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| AKT1 | SIRT6 | Ser338 | PKRERPTsPAPHRPP | phosphorylation down-regulates activity | 25074979 | SIGNOR-278465 |
| Enzyme | Effect | Phosphosite | Effect | Target | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| AKT1 | phosphorylation up-regulates → | SIRT6 PSer338 | phosphorylation down-regulates ⊣ | SIRT6 | 25074979 | SIGNOR-278465 |
| Regulator | Mechanism/Effect | Target | SIGNOR-ID |
|---|---|---|---|
| AKT1 | phosphorylation → down-regulates activity | SIRT6 | SIGNOR-278465 |