Entity Details

Name CGAS
ID Q8N884
Role substrate
Enzymatic Domains
View in

Data Summary
PTM Format
SIGNOR Summary
Modifier Substrate Residue Sequence Mechanism/Effect PMID Interaction ID
CDK1CGASSer305MKRKRGGsPAVTLLIphosphorylation
down-regulates activity		32351706SIGNOR-276526
SYKCGASTyr215LLNTGSYyEHVKISAphosphorylation
up-regulates activity		36252040SIGNOR-277845
BLKCGASTyr215LLNTGSYyEHVKISAphosphorylation
down-regulates activity		30356214SIGNOR-275844
SYKCGASTyr214GLLNTGSyYEHVKISphosphorylation
up-regulates activity		36252040SIGNOR-277844
PPP6CCGASSer435KHLDKFSsYHVKTAFdephosphorylation
down-regulates activity		32474700SIGNOR-276990
Enzyme Effect Phosphosite Effect Target PMID Interaction ID
CDK1phosphorylation
up-regulates
→
CGAS
PSer305		phosphorylation
down-regulates
⊣		CGAS32351706SIGNOR-276526
SYKphosphorylation
up-regulates
→
CGAS
PTyr215		phosphorylation
up-regulates
→		CGAS36252040SIGNOR-277845
BLKphosphorylation
up-regulates
→
CGAS
PTyr215		phosphorylation
down-regulates
⊣		CGAS30356214SIGNOR-275844
SYKphosphorylation
up-regulates
→
CGAS
PTyr214		phosphorylation
up-regulates
→		CGAS36252040SIGNOR-277844
PPP6Cdephosphorylation
down-regulates
⊣
CGAS
PSer435		dephosphorylation
up-regulates
→		CGAS32474700SIGNOR-276990
Regulator Mechanism/Effect Target SIGNOR-ID
CDK1phosphorylation
→
down-regulates activity 		CGASSIGNOR-276526
SYKphosphorylation
→
up-regulates activity 		CGASSIGNOR-277845
BLKphosphorylation
→
down-regulates activity 		CGASSIGNOR-275844
SYKphosphorylation
→
up-regulates activity 		CGASSIGNOR-277844
PPP6Cdephosphorylation
→
down-regulates activity 		CGASSIGNOR-276990