| Name | MLKL |
| ID | Q8NB16 |
| Role | substrate |
| Enzymatic Domains |
Protein kinase 194-469 PROSITE-ProRule |
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| Modifier | Substrate | Residue | Sequence | Mechanism/Effect | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| RIPK3 | MLKL | Thr357 | FELRKTQtSMSLGTT | phosphorylation up-regulates activity | 24012422 | SIGNOR-266438 |
| RIPK3 | MLKL | Ser358 | ELRKTQTsMSLGTTR | phosphorylation up-regulates activity | 24012422 | SIGNOR-266427 |
| TYRO3 | MLKL | Tyr376 | DRVKSTAyLSPQELE | phosphorylation up-regulates quantity by stabilization | 31230815 | SIGNOR-274120 |
| RIPK3 | MLKL | Thr357 | FELRKTQtSMSLGTT | phosphorylation up-regulates activity | 24012422 | SIGNOR-266429 |
| RIPK3 | MLKL | Ser358 | ELRKTQTsMSLGTTR | phosphorylation up-regulates activity | 24012422 | SIGNOR-266439 |
| RIPK3 | MLKL | Ser360 | RKTQTSMsLGTTREK | phosphorylation up-regulates activity | 24012422 | SIGNOR-266440 |
| AXL | MLKL | Tyr376 | DRVKSTAyLSPQELE | phosphorylation up-regulates quantity by stabilization | 31230815 | SIGNOR-274119 |
| MERTK | MLKL | Tyr376 | DRVKSTAyLSPQELE | phosphorylation up-regulates quantity by stabilization | 31230815 | SIGNOR-274118 |
| RIPK3 | MLKL | Ser360 | RKTQTSMsLGTTREK | phosphorylation up-regulates activity | 24012422 | SIGNOR-266428 |
| Enzyme | Effect | Phosphosite | Effect | Target | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| RIPK3 | phosphorylation up-regulates → | MLKL PThr357 | phosphorylation up-regulates → | MLKL | 24012422 | SIGNOR-266438 |
| RIPK3 | phosphorylation up-regulates → | MLKL PSer358 | phosphorylation up-regulates → | MLKL | 24012422 | SIGNOR-266427 |
| TYRO3 | phosphorylation up-regulates → | MLKL PTyr376 | phosphorylation up-regulates → | MLKL | 31230815 | SIGNOR-274120 |
| RIPK3 | phosphorylation up-regulates → | MLKL PThr357 | phosphorylation up-regulates → | MLKL | 24012422 | SIGNOR-266429 |
| RIPK3 | phosphorylation up-regulates → | MLKL PSer358 | phosphorylation up-regulates → | MLKL | 24012422 | SIGNOR-266439 |
| RIPK3 | phosphorylation up-regulates → | MLKL PSer360 | phosphorylation up-regulates → | MLKL | 24012422 | SIGNOR-266440 |
| AXL | phosphorylation up-regulates → | MLKL PTyr376 | phosphorylation up-regulates → | MLKL | 31230815 | SIGNOR-274119 |
| MERTK | phosphorylation up-regulates → | MLKL PTyr376 | phosphorylation up-regulates → | MLKL | 31230815 | SIGNOR-274118 |
| RIPK3 | phosphorylation up-regulates → | MLKL PSer360 | phosphorylation up-regulates → | MLKL | 24012422 | SIGNOR-266428 |
| Regulator | Mechanism/Effect | Target | SIGNOR-ID |
|---|---|---|---|
| RIPK3 | phosphorylation → up-regulates activity | MLKL | SIGNOR-266438 |
| RIPK3 | phosphorylation → up-regulates activity | MLKL | SIGNOR-266427 |
| TYRO3 | phosphorylation → up-regulates quantity by stabilization | MLKL | SIGNOR-274120 |
| RIPK3 | phosphorylation → up-regulates activity | MLKL | SIGNOR-266429 |
| RIPK3 | phosphorylation → up-regulates activity | MLKL | SIGNOR-266439 |
| RIPK3 | phosphorylation → up-regulates activity | MLKL | SIGNOR-266440 |
| AXL | phosphorylation → up-regulates quantity by stabilization | MLKL | SIGNOR-274119 |
| MERTK | phosphorylation → up-regulates quantity by stabilization | MLKL | SIGNOR-274118 |
| RIPK3 | phosphorylation → up-regulates activity | MLKL | SIGNOR-266428 |