Entity Details

Name MLKL
ID Q8NB16
Role substrate
Enzymatic Domains
Protein kinase 194-469
PROSITE-ProRule
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Data Summary
PTM Format
SIGNOR Summary
Modifier Substrate Residue Sequence Mechanism/Effect PMID Interaction ID
MERTKMLKLTyr376DRVKSTAyLSPQELEphosphorylation
up-regulates quantity by stabilization		31230815SIGNOR-274118
RIPK3MLKLSer360RKTQTSMsLGTTREKphosphorylation
up-regulates activity		24012422SIGNOR-266440
TYRO3MLKLTyr376DRVKSTAyLSPQELEphosphorylation
up-regulates quantity by stabilization		31230815SIGNOR-274120
RIPK3MLKLThr357FELRKTQtSMSLGTTphosphorylation
up-regulates activity		24012422SIGNOR-266438
RIPK3MLKLThr357FELRKTQtSMSLGTTphosphorylation
up-regulates activity		24012422SIGNOR-266429
RIPK3MLKLSer360RKTQTSMsLGTTREKphosphorylation
up-regulates activity		24012422SIGNOR-266428
RIPK3MLKLSer358
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ELRKTQTsMSLGTTRphosphorylation
up-regulates activity		24012422SIGNOR-266439
RIPK3MLKLSer358
View in OncoXplorer
ELRKTQTsMSLGTTRphosphorylation
up-regulates activity		24012422SIGNOR-266427
AXLMLKLTyr376DRVKSTAyLSPQELEphosphorylation
up-regulates quantity by stabilization		31230815SIGNOR-274119
Enzyme Effect Phosphosite Effect Target PMID Interaction ID
MERTKphosphorylation
up-regulates
→
MLKL
PTyr376		phosphorylation
up-regulates
→		MLKL31230815SIGNOR-274118
RIPK3phosphorylation
up-regulates
→
MLKL
PSer360		phosphorylation
up-regulates
→		MLKL24012422SIGNOR-266440
TYRO3phosphorylation
up-regulates
→
MLKL
PTyr376		phosphorylation
up-regulates
→		MLKL31230815SIGNOR-274120
RIPK3phosphorylation
up-regulates
→
MLKL
PThr357		phosphorylation
up-regulates
→		MLKL24012422SIGNOR-266438
RIPK3phosphorylation
up-regulates
→
MLKL
PThr357		phosphorylation
up-regulates
→		MLKL24012422SIGNOR-266429
RIPK3phosphorylation
up-regulates
→
MLKL
PSer360		phosphorylation
up-regulates
→		MLKL24012422SIGNOR-266428
RIPK3phosphorylation
up-regulates
→
MLKL
PSer358		phosphorylation
up-regulates
→		MLKL24012422SIGNOR-266439
RIPK3phosphorylation
up-regulates
→
MLKL
PSer358		phosphorylation
up-regulates
→		MLKL24012422SIGNOR-266427
AXLphosphorylation
up-regulates
→
MLKL
PTyr376		phosphorylation
up-regulates
→		MLKL31230815SIGNOR-274119
Regulator Mechanism/Effect Target SIGNOR-ID
MERTKphosphorylation
→
up-regulates quantity by stabilization 		MLKLSIGNOR-274118
RIPK3phosphorylation
→
up-regulates activity 		MLKLSIGNOR-266440
TYRO3phosphorylation
→
up-regulates quantity by stabilization 		MLKLSIGNOR-274120
RIPK3phosphorylation
→
up-regulates activity 		MLKLSIGNOR-266438
RIPK3phosphorylation
→
up-regulates activity 		MLKLSIGNOR-266429
RIPK3phosphorylation
→
up-regulates activity 		MLKLSIGNOR-266428
RIPK3phosphorylation
→
up-regulates activity 		MLKLSIGNOR-266439
RIPK3phosphorylation
→
up-regulates activity 		MLKLSIGNOR-266427
AXLphosphorylation
→
up-regulates quantity by stabilization 		MLKLSIGNOR-274119