Modifier	Substrate	Residue	Sequence	Mechanism/Effect	PMID	Interaction ID
CDK5	PIK3C3	Thr668	ENLDLKLtPYKVLAT	phosphorylation down-regulates activity	20513426	SIGNOR-259811
ULK1	PIK3C3	–		phosphorylation up-regulates activity	29671878	SIGNOR-279670
CDK5	PIK3C3	Thr159	DGSEPTKtPGRTSST	phosphorylation down-regulates	20513426	SIGNOR-165772
CDK1	PIK3C3	Thr159	DGSEPTKtPGRTSST	phosphorylation down-regulates	20513426	SIGNOR-165768
SRC	PIK3C3	–		phosphorylation up-regulates activity	24582588	SIGNOR-278456
PRKD1	PIK3C3	Thr677	YKVLATStKHGFMQF	phosphorylation up-regulates activity	22095288	SIGNOR-278495

Enzyme	Effect	Phosphosite	Effect	Target	PMID	Interaction ID
CDK5	phosphorylation up-regulates →	PIK3C3 PThr668	phosphorylation down-regulates ⊣	PIK3C3	20513426	SIGNOR-259811
CDK5	phosphorylation up-regulates →	PIK3C3 PThr159	phosphorylation down-regulates ⊣	PIK3C3	20513426	SIGNOR-165772
CDK1	phosphorylation up-regulates →	PIK3C3 PThr159	phosphorylation down-regulates ⊣	PIK3C3	20513426	SIGNOR-165768
PRKD1	phosphorylation up-regulates →	PIK3C3 PThr677	phosphorylation up-regulates →	PIK3C3	22095288	SIGNOR-278495

Regulator	Mechanism/Effect	Target	SIGNOR-ID
CDK5	phosphorylation → down-regulates activity	PIK3C3	SIGNOR-259811
ULK1	phosphorylation → up-regulates activity	PIK3C3	SIGNOR-279670
CDK5	phosphorylation down-regulates	PIK3C3	SIGNOR-165772
CDK1	phosphorylation down-regulates	PIK3C3	SIGNOR-165768
SRC	phosphorylation → up-regulates activity	PIK3C3	SIGNOR-278456
PRKD1	phosphorylation → up-regulates activity	PIK3C3	SIGNOR-278495