| Modifier | Substrate | Residue | Sequence | Mechanism/Effect | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| PRKCE | TRPV1 | Ser821 | YLRQFSGsLKPEDAE | phosphorylation up-regulates activity | 14523239 | SIGNOR-249233 |
| PRKCE | TRPV1 | Ser502 | YFLQRRPsMKTLFVD | phosphorylation up-regulates activity | 11884385 | SIGNOR-249141 |
| PTPN6 | TRPV1 | – | dephosphorylation down-regulates activity | 25790452 | SIGNOR-277129 | |
| PRKCE | TRPV1 | Ser502 | YFLQRRPsMKTLFVD | phosphorylation up-regulates activity | 14523239 | SIGNOR-249230 |
| PRKCE | TRPV1 | Thr705 | WKLQRAItILDTEKS | phosphorylation up-regulates activity | 14523239 | SIGNOR-249235 |
| CDK5 | TRPV1 | – | phosphorylation up-regulates activity | 26894912 | SIGNOR-278437 | |
| PRKCB | TRPV1 | Thr705 | WKLQRAItILDTEKS | phosphorylation up-regulates activity | 24920628 | SIGNOR-276638 |
| PRKCE | TRPV1 | Ser801 | VPLLREAsARDRQSA | phosphorylation up-regulates activity | 11884385 | SIGNOR-249142 |
| PRKCE | TRPV1 | Ser801 | VPLLREAsARDRQSA | phosphorylation up-regulates activity | 14523239 | SIGNOR-249232 |
| PRKCE | TRPV1 | Ser775 | EGVKRTLsFSLRSSR | phosphorylation up-regulates activity | 14523239 | SIGNOR-249231 |
| PRKCE | TRPV1 | Thr145 | QKSKKHLtDNEFKDP | phosphorylation up-regulates activity | 14523239 | SIGNOR-249234 |
| Enzyme | Effect | Phosphosite | Effect | Target | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| PRKCE | phosphorylation up-regulates → | TRPV1 PSer821 | phosphorylation up-regulates → | TRPV1 | 14523239 | SIGNOR-249233 |
| PRKCE | phosphorylation up-regulates → | TRPV1 PSer502 | phosphorylation up-regulates → | TRPV1 | 11884385 | SIGNOR-249141 |
| PRKCE | phosphorylation up-regulates → | TRPV1 PSer502 | phosphorylation up-regulates → | TRPV1 | 14523239 | SIGNOR-249230 |
| PRKCE | phosphorylation up-regulates → | TRPV1 PThr705 | phosphorylation up-regulates → | TRPV1 | 14523239 | SIGNOR-249235 |
| PRKCB | phosphorylation up-regulates → | TRPV1 PThr705 | phosphorylation up-regulates → | TRPV1 | 24920628 | SIGNOR-276638 |
| PRKCE | phosphorylation up-regulates → | TRPV1 PSer801 | phosphorylation up-regulates → | TRPV1 | 11884385 | SIGNOR-249142 |
| PRKCE | phosphorylation up-regulates → | TRPV1 PSer801 | phosphorylation up-regulates → | TRPV1 | 14523239 | SIGNOR-249232 |
| PRKCE | phosphorylation up-regulates → | TRPV1 PSer775 | phosphorylation up-regulates → | TRPV1 | 14523239 | SIGNOR-249231 |
| PRKCE | phosphorylation up-regulates → | TRPV1 PThr145 | phosphorylation up-regulates → | TRPV1 | 14523239 | SIGNOR-249234 |
| Regulator | Mechanism/Effect | Target | SIGNOR-ID |
|---|---|---|---|
| PRKCE | phosphorylation → up-regulates activity | TRPV1 | SIGNOR-249233 |
| PRKCE | phosphorylation → up-regulates activity | TRPV1 | SIGNOR-249141 |
| PTPN6 | dephosphorylation → down-regulates activity | TRPV1 | SIGNOR-277129 |
| PRKCE | phosphorylation → up-regulates activity | TRPV1 | SIGNOR-249230 |
| PRKCE | phosphorylation → up-regulates activity | TRPV1 | SIGNOR-249235 |
| CDK5 | phosphorylation → up-regulates activity | TRPV1 | SIGNOR-278437 |
| PRKCB | phosphorylation → up-regulates activity | TRPV1 | SIGNOR-276638 |
| PRKCE | phosphorylation → up-regulates activity | TRPV1 | SIGNOR-249142 |
| PRKCE | phosphorylation → up-regulates activity | TRPV1 | SIGNOR-249232 |
| PRKCE | phosphorylation → up-regulates activity | TRPV1 | SIGNOR-249231 |
| PRKCE | phosphorylation → up-regulates activity | TRPV1 | SIGNOR-249234 |
