| Modifier | Substrate | Residue | Sequence | Mechanism/Effect | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| EGFR | GPRC5A | Tyr350 | WPSPYKDyEVKKEGS | phosphorylation down-regulates activity | 25311788 | SIGNOR-278336 |
| EGFR | GPRC5A | Tyr320 | GDTLYAPySTHFQLQ | phosphorylation down-regulates activity | 25311788 | SIGNOR-278334 |
| EGFR | GPRC5A | Tyr317 | EETGDTLyAPYSTHF | phosphorylation down-regulates activity | 25311788 | SIGNOR-278333 |
| EGFR | GPRC5A | Tyr347 | AHAWPSPyKDYEVKK | phosphorylation down-regulates activity | 25311788 | SIGNOR-278335 |
| Enzyme | Effect | Phosphosite | Effect | Target | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| EGFR | phosphorylation up-regulates → | GPRC5A PTyr350 | phosphorylation down-regulates ⊣ | GPRC5A | 25311788 | SIGNOR-278336 |
| EGFR | phosphorylation up-regulates → | GPRC5A PTyr320 | phosphorylation down-regulates ⊣ | GPRC5A | 25311788 | SIGNOR-278334 |
| EGFR | phosphorylation up-regulates → | GPRC5A PTyr317 | phosphorylation down-regulates ⊣ | GPRC5A | 25311788 | SIGNOR-278333 |
| EGFR | phosphorylation up-regulates → | GPRC5A PTyr347 | phosphorylation down-regulates ⊣ | GPRC5A | 25311788 | SIGNOR-278335 |
| Regulator | Mechanism/Effect | Target | SIGNOR-ID |
|---|---|---|---|
| EGFR | phosphorylation → down-regulates activity | GPRC5A | SIGNOR-278336 |
| EGFR | phosphorylation → down-regulates activity | GPRC5A | SIGNOR-278334 |
| EGFR | phosphorylation → down-regulates activity | GPRC5A | SIGNOR-278333 |
| EGFR | phosphorylation → down-regulates activity | GPRC5A | SIGNOR-278335 |
