| Modifier | Substrate | Residue | Sequence | Mechanism/Effect | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| PLK1 | NEDD1 | Ser426 | VNKGSDEsIGKGDGF | phosphorylation up-regulates activity | 19509060 | SIGNOR-272992 |
| PLK1 | NEDD1 | Thr382 | PRSINTDtLSKETDS | phosphorylation up-regulates activity | 19509060 | SIGNOR-272993 |
| PLK1 | NEDD1 | Ser637 | HSLLERYsVNEGLVA | phosphorylation up-regulates activity | 19509060 | SIGNOR-272991 |
| CDK1 | NEDD1 | Ser460 | STSVLHSsPLNVFMG | phosphorylation up-regulates activity | 21690413 | SIGNOR-272972 |
| AURKA | NEDD1 | Ser405 | FDDTGKSsLGDMFSP | phosphorylation up-regulates activity | 31028180 | SIGNOR-272965 |
| PLK1 | NEDD1 | Ser397 | GKNQDFSsFDDTGKS | phosphorylation up-regulates activity | 19509060 | SIGNOR-272994 |
| CDK1 | NEDD1 | Thr550 | PPINGSStPNPKIAS | phosphorylation up-regulates activity | 19509060 | SIGNOR-272973 |
| NEK9 | NEDD1 | Ser377 | EKAGLPRsINTDTLS | phosphorylation up-regulates activity | 22818914 | SIGNOR-263016 |
| PLK4 | NEDD1 | Ser325 | PTTVNKRsVNVNAAS | phosphorylation up-regulates activity | 33351100 | SIGNOR-272996 |
| Enzyme | Effect | Phosphosite | Effect | Target | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| PLK1 | phosphorylation up-regulates → | NEDD1 PSer426 | phosphorylation up-regulates → | NEDD1 | 19509060 | SIGNOR-272992 |
| PLK1 | phosphorylation up-regulates → | NEDD1 PThr382 | phosphorylation up-regulates → | NEDD1 | 19509060 | SIGNOR-272993 |
| PLK1 | phosphorylation up-regulates → | NEDD1 PSer637 | phosphorylation up-regulates → | NEDD1 | 19509060 | SIGNOR-272991 |
| CDK1 | phosphorylation up-regulates → | NEDD1 PSer460 | phosphorylation up-regulates → | NEDD1 | 21690413 | SIGNOR-272972 |
| AURKA | phosphorylation up-regulates → | NEDD1 PSer405 | phosphorylation up-regulates → | NEDD1 | 31028180 | SIGNOR-272965 |
| PLK1 | phosphorylation up-regulates → | NEDD1 PSer397 | phosphorylation up-regulates → | NEDD1 | 19509060 | SIGNOR-272994 |
| CDK1 | phosphorylation up-regulates → | NEDD1 PThr550 | phosphorylation up-regulates → | NEDD1 | 19509060 | SIGNOR-272973 |
| NEK9 | phosphorylation up-regulates → | NEDD1 PSer377 | phosphorylation up-regulates → | NEDD1 | 22818914 | SIGNOR-263016 |
| PLK4 | phosphorylation up-regulates → | NEDD1 PSer325 | phosphorylation up-regulates → | NEDD1 | 33351100 | SIGNOR-272996 |
| Regulator | Mechanism/Effect | Target | SIGNOR-ID |
|---|---|---|---|
| PLK1 | phosphorylation → up-regulates activity | NEDD1 | SIGNOR-272992 |
| PLK1 | phosphorylation → up-regulates activity | NEDD1 | SIGNOR-272993 |
| PLK1 | phosphorylation → up-regulates activity | NEDD1 | SIGNOR-272991 |
| CDK1 | phosphorylation → up-regulates activity | NEDD1 | SIGNOR-272972 |
| AURKA | phosphorylation → up-regulates activity | NEDD1 | SIGNOR-272965 |
| PLK1 | phosphorylation → up-regulates activity | NEDD1 | SIGNOR-272994 |
| CDK1 | phosphorylation → up-regulates activity | NEDD1 | SIGNOR-272973 |
| NEK9 | phosphorylation → up-regulates activity | NEDD1 | SIGNOR-263016 |
| PLK4 | phosphorylation → up-regulates activity | NEDD1 | SIGNOR-272996 |
