| Name | MAFA |
| ID | Q8NHW3 |
| Role | substrate |
| Enzymatic Domains |
bZIP 254-317 PROSITE-ProRule |
View in  |
|
| Modifier | Substrate | Residue | Sequence | Mechanism/Effect | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| GSK3A | MAFA | Ser61 | PLSTPCSsVPSSPSF | phosphorylation up-regulates activity | 18042454 | SIGNOR-159369 |
| GSK3B | MAFA | Thr53 | PPGSLSStPLSTPCS | phosphorylation up-regulates activity | 18042454 | SIGNOR-159450 |
| GSK3A | MAFA | Ser49 | CHRLPPGsLSSTPLS | phosphorylation down-regulates quantity by destabilization | 18042454 | SIGNOR-159381 |
| GSK3A | MAFA | Thr57 | LSSTPLStPCSSVPS | phosphorylation down-regulates quantity by destabilization | 18042454 | SIGNOR-159398 |
| MAPK1 | MAFA | Ser14 | MGAELPSsPLAIEYV | phosphorylation up-regulates activity | 11416124 | SIGNOR-275976 |
| GSK3B | MAFA | Ser49 | CHRLPPGsLSSTPLS | phosphorylation up-regulates activity | 18042454 | SIGNOR-159442 |
| GSK3A | MAFA | Ser61 | PLSTPCSsVPSSPSF | phosphorylation down-regulates quantity by destabilization | 18042454 | SIGNOR-159390 |
| MAPK1 | MAFA | Ser14 | MGAELPSsPLAIEYV | phosphorylation up-regulates activity | 11416124 | SIGNOR-108560 |
| GSK3A | MAFA | Ser49 | CHRLPPGsLSSTPLS | phosphorylation up-regulates activity | 18042454 | SIGNOR-159365 |
| GSK3B | MAFA | Thr57 | LSSTPLStPCSSVPS | phosphorylation down-regulates quantity by destabilization | 18042454 | SIGNOR-159470 |
| GSK3A | MAFA | Thr57 | LSSTPLStPCSSVPS | phosphorylation up-regulates activity | 18042454 | SIGNOR-159377 |
| GSK3B | MAFA | Ser49 | CHRLPPGsLSSTPLS | phosphorylation down-regulates quantity by destabilization | 18042454 | SIGNOR-159458 |
| GSK3A | MAFA | Thr53 | PPGSLSStPLSTPCS | phosphorylation up-regulates activity | 18042454 | SIGNOR-159373 |
| MAPK1 | MAFA | Ser65 | PCSSVPSsPSFCAPS | phosphorylation up-regulates activity | 11416124 | SIGNOR-108564 |
| GSK3A | MAFA | Thr53 | PPGSLSStPLSTPCS | phosphorylation down-regulates quantity by destabilization | 18042454 | SIGNOR-159394 |
| GSK3B | MAFA | Ser61 | PLSTPCSsVPSSPSF | phosphorylation up-regulates activity | 18042454 | SIGNOR-159446 |
| GSK3B | MAFA | Thr53 | PPGSLSStPLSTPCS | phosphorylation down-regulates quantity by destabilization | 18042454 | SIGNOR-159466 |
| MAPK1 | MAFA | Ser65 | PCSSVPSsPSFCAPS | phosphorylation up-regulates activity | 11416124 | SIGNOR-275977 |
| GSK3B | MAFA | Thr57 | LSSTPLStPCSSVPS | phosphorylation up-regulates activity | 18042454 | SIGNOR-159454 |
| GSK3B | MAFA | Ser61 | PLSTPCSsVPSSPSF | phosphorylation down-regulates quantity by destabilization | 18042454 | SIGNOR-159462 |
| Enzyme | Effect | Phosphosite | Effect | Target | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| GSK3A | phosphorylation up-regulates → | MAFA PSer61 | phosphorylation up-regulates → | MAFA | 18042454 | SIGNOR-159369 |
| GSK3B | phosphorylation up-regulates → | MAFA PThr53 | phosphorylation up-regulates → | MAFA | 18042454 | SIGNOR-159450 |
| GSK3A | phosphorylation up-regulates → | MAFA PSer49 | phosphorylation down-regulates ⊣ | MAFA | 18042454 | SIGNOR-159381 |
| GSK3A | phosphorylation up-regulates → | MAFA PThr57 | phosphorylation down-regulates ⊣ | MAFA | 18042454 | SIGNOR-159398 |
| MAPK1 | phosphorylation up-regulates → | MAFA PSer14 | phosphorylation up-regulates → | MAFA | 11416124 | SIGNOR-275976 |
| GSK3B | phosphorylation up-regulates → | MAFA PSer49 | phosphorylation up-regulates → | MAFA | 18042454 | SIGNOR-159442 |
| GSK3A | phosphorylation up-regulates → | MAFA PSer61 | phosphorylation down-regulates ⊣ | MAFA | 18042454 | SIGNOR-159390 |
| MAPK1 | phosphorylation up-regulates → | MAFA PSer14 | phosphorylation up-regulates → | MAFA | 11416124 | SIGNOR-108560 |
| GSK3A | phosphorylation up-regulates → | MAFA PSer49 | phosphorylation up-regulates → | MAFA | 18042454 | SIGNOR-159365 |
| GSK3B | phosphorylation up-regulates → | MAFA PThr57 | phosphorylation down-regulates ⊣ | MAFA | 18042454 | SIGNOR-159470 |
| GSK3A | phosphorylation up-regulates → | MAFA PThr57 | phosphorylation up-regulates → | MAFA | 18042454 | SIGNOR-159377 |
| GSK3B | phosphorylation up-regulates → | MAFA PSer49 | phosphorylation down-regulates ⊣ | MAFA | 18042454 | SIGNOR-159458 |
| GSK3A | phosphorylation up-regulates → | MAFA PThr53 | phosphorylation up-regulates → | MAFA | 18042454 | SIGNOR-159373 |
| MAPK1 | phosphorylation up-regulates → | MAFA PSer65 | phosphorylation up-regulates → | MAFA | 11416124 | SIGNOR-108564 |
| GSK3A | phosphorylation up-regulates → | MAFA PThr53 | phosphorylation down-regulates ⊣ | MAFA | 18042454 | SIGNOR-159394 |
| GSK3B | phosphorylation up-regulates → | MAFA PSer61 | phosphorylation up-regulates → | MAFA | 18042454 | SIGNOR-159446 |
| GSK3B | phosphorylation up-regulates → | MAFA PThr53 | phosphorylation down-regulates ⊣ | MAFA | 18042454 | SIGNOR-159466 |
| MAPK1 | phosphorylation up-regulates → | MAFA PSer65 | phosphorylation up-regulates → | MAFA | 11416124 | SIGNOR-275977 |
| GSK3B | phosphorylation up-regulates → | MAFA PThr57 | phosphorylation up-regulates → | MAFA | 18042454 | SIGNOR-159454 |
| GSK3B | phosphorylation up-regulates → | MAFA PSer61 | phosphorylation down-regulates ⊣ | MAFA | 18042454 | SIGNOR-159462 |
| Regulator | Mechanism/Effect | Target | SIGNOR-ID |
|---|---|---|---|
| GSK3A | phosphorylation → up-regulates activity | MAFA | SIGNOR-159369 |
| GSK3B | phosphorylation → up-regulates activity | MAFA | SIGNOR-159450 |
| GSK3A | phosphorylation down-regulates quantity by destabilization | MAFA | SIGNOR-159381 |
| GSK3A | phosphorylation down-regulates quantity by destabilization | MAFA | SIGNOR-159398 |
| MAPK1 | phosphorylation → up-regulates activity | MAFA | SIGNOR-275976 |
| GSK3B | phosphorylation → up-regulates activity | MAFA | SIGNOR-159442 |
| GSK3A | phosphorylation down-regulates quantity by destabilization | MAFA | SIGNOR-159390 |
| MAPK1 | phosphorylation → up-regulates activity | MAFA | SIGNOR-108560 |
| GSK3A | phosphorylation → up-regulates activity | MAFA | SIGNOR-159365 |
| GSK3B | phosphorylation down-regulates quantity by destabilization | MAFA | SIGNOR-159470 |
| GSK3A | phosphorylation → up-regulates activity | MAFA | SIGNOR-159377 |
| GSK3B | phosphorylation down-regulates quantity by destabilization | MAFA | SIGNOR-159458 |
| GSK3A | phosphorylation → up-regulates activity | MAFA | SIGNOR-159373 |
| MAPK1 | phosphorylation → up-regulates activity | MAFA | SIGNOR-108564 |
| GSK3A | phosphorylation down-regulates quantity by destabilization | MAFA | SIGNOR-159394 |
| GSK3B | phosphorylation → up-regulates activity | MAFA | SIGNOR-159446 |
| GSK3B | phosphorylation down-regulates quantity by destabilization | MAFA | SIGNOR-159466 |
| MAPK1 | phosphorylation → up-regulates activity | MAFA | SIGNOR-275977 |
| GSK3B | phosphorylation → up-regulates activity | MAFA | SIGNOR-159454 |
| GSK3B | phosphorylation down-regulates quantity by destabilization | MAFA | SIGNOR-159462 |