| Name | DEPTOR |
| ID | Q8TB45 |
| Role | substrate |
| Enzymatic Domains |
DEP 1 36-119 PROSITE-ProRule
DEP 2 145-219 PROSITE-ProRule
PDZ 330-407 PROSITE-ProRule |
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| Modifier | Substrate | Residue | Sequence | Mechanism/Effect | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| RPS6KA1 | DEPTOR | Ser291 | CGSSGYFsSSPTLSS | phosphorylation down-regulates | 22017877 | SIGNOR-176891 |
| RPS6K | DEPTOR | Ser286 | SSMSSCGsSGYFSSS | phosphorylation down-regulates | 22017877 | SIGNOR-252797 |
| CSNK1A1 | DEPTOR | Ser286 | SSMSSCGsSGYFSSS | phosphorylation down-regulates | 22017877 | SIGNOR-176871 |
| CSNK1A1 | DEPTOR | Ser291 | CGSSGYFsSSPTLSS | phosphorylation down-regulates | 22017877 | SIGNOR-176879 |
| SYK | DEPTOR | Tyr289 | SSCGSSGyFSSSPTL | phosphorylation down-regulates activity | 34634301 | SIGNOR-277572 |
| RPS6K | DEPTOR | Ser291 | CGSSGYFsSSPTLSS | phosphorylation down-regulates | 22017877 | SIGNOR-252799 |
| CHKA | DEPTOR | Ser287 | SMSSCGSsGYFSSSP | phosphorylation down-regulates quantity by destabilization | 22017875 | SIGNOR-279605 |
| MTOR | DEPTOR | Ser299 | SSPTLSSsPPVLCNP | phosphorylation down-regulates | 22017875 | SIGNOR-176853 |
| RPS6KB1 | DEPTOR | Ser287 | SMSSCGSsGYFSSSP | phosphorylation down-regulates | 22017876 | SIGNOR-176862 |
| CSNK1A1 | DEPTOR | Ser287 | SMSSCGSsGYFSSSP | phosphorylation down-regulates | 22017877 | SIGNOR-176875 |
| CHKA | DEPTOR | Ser286 | SSMSSCGsSGYFSSS | phosphorylation down-regulates quantity by destabilization | 22017875 | SIGNOR-279604 |
| RPS6KA1 | DEPTOR | Ser287 | SMSSCGSsGYFSSSP | phosphorylation down-regulates | 22017877 | SIGNOR-176887 |
| RPS6KB1 | DEPTOR | Ser286 | SSMSSCGsSGYFSSS | phosphorylation down-regulates | 22017876 | SIGNOR-176858 |
| MAPK3 | DEPTOR | Ser235 | MELLNEKsPSSQETH | phosphorylation up-regulates quantity by stabilization | 35216969 | SIGNOR-277587 |
| RPS6KA1 | DEPTOR | Ser286 | SSMSSCGsSGYFSSS | phosphorylation down-regulates | 22017877 | SIGNOR-176883 |
| RPS6K | DEPTOR | Ser287 | SMSSCGSsGYFSSSP | phosphorylation down-regulates | 22017877 | SIGNOR-252798 |
| MTOR | DEPTOR | Ser293 | SSGYFSSsPTLSSSP | phosphorylation down-regulates | 22017875 | SIGNOR-176849 |
| RPS6KB1 | DEPTOR | Ser291 | CGSSGYFsSSPTLSS | phosphorylation down-regulates | 22017876 | SIGNOR-176866 |
| Enzyme | Effect | Phosphosite | Effect | Target | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| RPS6KA1 | phosphorylation up-regulates → | DEPTOR PSer291 | phosphorylation down-regulates ⊣ | DEPTOR | 22017877 | SIGNOR-176891 |
| RPS6K | phosphorylation up-regulates → | DEPTOR PSer286 | phosphorylation down-regulates ⊣ | DEPTOR | 22017877 | SIGNOR-252797 |
| CSNK1A1 | phosphorylation up-regulates → | DEPTOR PSer286 | phosphorylation down-regulates ⊣ | DEPTOR | 22017877 | SIGNOR-176871 |
| CSNK1A1 | phosphorylation up-regulates → | DEPTOR PSer291 | phosphorylation down-regulates ⊣ | DEPTOR | 22017877 | SIGNOR-176879 |
| SYK | phosphorylation up-regulates → | DEPTOR PTyr289 | phosphorylation down-regulates ⊣ | DEPTOR | 34634301 | SIGNOR-277572 |
| RPS6K | phosphorylation up-regulates → | DEPTOR PSer291 | phosphorylation down-regulates ⊣ | DEPTOR | 22017877 | SIGNOR-252799 |
| CHKA | phosphorylation up-regulates → | DEPTOR PSer287 | phosphorylation down-regulates ⊣ | DEPTOR | 22017875 | SIGNOR-279605 |
| MTOR | phosphorylation up-regulates → | DEPTOR PSer299 | phosphorylation down-regulates ⊣ | DEPTOR | 22017875 | SIGNOR-176853 |
| RPS6KB1 | phosphorylation up-regulates → | DEPTOR PSer287 | phosphorylation down-regulates ⊣ | DEPTOR | 22017876 | SIGNOR-176862 |
| CSNK1A1 | phosphorylation up-regulates → | DEPTOR PSer287 | phosphorylation down-regulates ⊣ | DEPTOR | 22017877 | SIGNOR-176875 |
| CHKA | phosphorylation up-regulates → | DEPTOR PSer286 | phosphorylation down-regulates ⊣ | DEPTOR | 22017875 | SIGNOR-279604 |
| RPS6KA1 | phosphorylation up-regulates → | DEPTOR PSer287 | phosphorylation down-regulates ⊣ | DEPTOR | 22017877 | SIGNOR-176887 |
| RPS6KB1 | phosphorylation up-regulates → | DEPTOR PSer286 | phosphorylation down-regulates ⊣ | DEPTOR | 22017876 | SIGNOR-176858 |
| MAPK3 | phosphorylation up-regulates → | DEPTOR PSer235 | phosphorylation up-regulates → | DEPTOR | 35216969 | SIGNOR-277587 |
| RPS6KA1 | phosphorylation up-regulates → | DEPTOR PSer286 | phosphorylation down-regulates ⊣ | DEPTOR | 22017877 | SIGNOR-176883 |
| RPS6K | phosphorylation up-regulates → | DEPTOR PSer287 | phosphorylation down-regulates ⊣ | DEPTOR | 22017877 | SIGNOR-252798 |
| MTOR | phosphorylation up-regulates → | DEPTOR PSer293 | phosphorylation down-regulates ⊣ | DEPTOR | 22017875 | SIGNOR-176849 |
| RPS6KB1 | phosphorylation up-regulates → | DEPTOR PSer291 | phosphorylation down-regulates ⊣ | DEPTOR | 22017876 | SIGNOR-176866 |
| Regulator | Mechanism/Effect | Target | SIGNOR-ID |
|---|---|---|---|
| RPS6KA1 | phosphorylation down-regulates | DEPTOR | SIGNOR-176891 |
| RPS6K | phosphorylation down-regulates | DEPTOR | SIGNOR-252797 |
| CSNK1A1 | phosphorylation down-regulates | DEPTOR | SIGNOR-176871 |
| CSNK1A1 | phosphorylation down-regulates | DEPTOR | SIGNOR-176879 |
| SYK | phosphorylation → down-regulates activity | DEPTOR | SIGNOR-277572 |
| RPS6K | phosphorylation down-regulates | DEPTOR | SIGNOR-252799 |
| CHKA | phosphorylation down-regulates quantity by destabilization | DEPTOR | SIGNOR-279605 |
| MTOR | phosphorylation down-regulates | DEPTOR | SIGNOR-176853 |
| RPS6KB1 | phosphorylation down-regulates | DEPTOR | SIGNOR-176862 |
| CSNK1A1 | phosphorylation down-regulates | DEPTOR | SIGNOR-176875 |
| CHKA | phosphorylation down-regulates quantity by destabilization | DEPTOR | SIGNOR-279604 |
| RPS6KA1 | phosphorylation down-regulates | DEPTOR | SIGNOR-176887 |
| RPS6KB1 | phosphorylation down-regulates | DEPTOR | SIGNOR-176858 |
| MAPK3 | phosphorylation → up-regulates quantity by stabilization | DEPTOR | SIGNOR-277587 |
| RPS6KA1 | phosphorylation down-regulates | DEPTOR | SIGNOR-176883 |
| RPS6K | phosphorylation down-regulates | DEPTOR | SIGNOR-252798 |
| MTOR | phosphorylation down-regulates | DEPTOR | SIGNOR-176849 |
| RPS6KB1 | phosphorylation down-regulates | DEPTOR | SIGNOR-176866 |