Modifier	Substrate	Residue	Sequence	Mechanism/Effect	PMID	Interaction ID
CHKA	DEPTOR	Ser286 View in OncoXplorer	SSMSSCGsSGYFSSS	phosphorylation down-regulates quantity by destabilization	22017875	SIGNOR-279604
CSNK1A1	DEPTOR	Ser287 View in OncoXplorer	SMSSCGSsGYFSSSP	phosphorylation down-regulates	22017877	SIGNOR-176875
RPS6KB1	DEPTOR	Ser286 View in OncoXplorer	SSMSSCGsSGYFSSS	phosphorylation down-regulates	22017876	SIGNOR-176858
RPS6KA1	DEPTOR	Ser287 View in OncoXplorer	SMSSCGSsGYFSSSP	phosphorylation down-regulates	22017877	SIGNOR-176887
CSNK1A1	DEPTOR	Ser291	CGSSGYFsSSPTLSS	phosphorylation down-regulates	22017877	SIGNOR-176879
MTOR	DEPTOR	Ser293 View in OncoXplorer	SSGYFSSsPTLSSSP	phosphorylation down-regulates	22017875	SIGNOR-176849
CSNK1A1	DEPTOR	Ser286 View in OncoXplorer	SSMSSCGsSGYFSSS	phosphorylation down-regulates	22017877	SIGNOR-176871
RPS6KB1	DEPTOR	Ser287 View in OncoXplorer	SMSSCGSsGYFSSSP	phosphorylation down-regulates	22017876	SIGNOR-176862
RPS6KA1	DEPTOR	Ser291	CGSSGYFsSSPTLSS	phosphorylation down-regulates	22017877	SIGNOR-176891
RPS6KA1	DEPTOR	Ser286 View in OncoXplorer	SSMSSCGsSGYFSSS	phosphorylation down-regulates	22017877	SIGNOR-176883
RPS6K	DEPTOR	Ser291	CGSSGYFsSSPTLSS	phosphorylation down-regulates	22017877	SIGNOR-252799
MAPK3	DEPTOR	Ser235 View in OncoXplorer	MELLNEKsPSSQETH	phosphorylation up-regulates quantity by stabilization	35216969	SIGNOR-277587
CHKA	DEPTOR	Ser287 View in OncoXplorer	SMSSCGSsGYFSSSP	phosphorylation down-regulates quantity by destabilization	22017875	SIGNOR-279605
RPS6K	DEPTOR	Ser287 View in OncoXplorer	SMSSCGSsGYFSSSP	phosphorylation down-regulates	22017877	SIGNOR-252798
RPS6KB1	DEPTOR	Ser291	CGSSGYFsSSPTLSS	phosphorylation down-regulates	22017876	SIGNOR-176866
MTOR	DEPTOR	Ser299 View in OncoXplorer	SSPTLSSsPPVLCNP	phosphorylation down-regulates	22017875	SIGNOR-176853
SYK	DEPTOR	Tyr289 View in OncoXplorer	SSCGSSGyFSSSPTL	phosphorylation down-regulates activity	34634301	SIGNOR-277572
RPS6K	DEPTOR	Ser286 View in OncoXplorer	SSMSSCGsSGYFSSS	phosphorylation down-regulates	22017877	SIGNOR-252797

Enzyme	Effect	Phosphosite	Effect	Target	PMID	Interaction ID
CHKA	phosphorylation up-regulates →	DEPTOR PSer286	phosphorylation down-regulates ⊣	DEPTOR	22017875	SIGNOR-279604
CSNK1A1	phosphorylation up-regulates →	DEPTOR PSer287	phosphorylation down-regulates ⊣	DEPTOR	22017877	SIGNOR-176875
RPS6KB1	phosphorylation up-regulates →	DEPTOR PSer286	phosphorylation down-regulates ⊣	DEPTOR	22017876	SIGNOR-176858
RPS6KA1	phosphorylation up-regulates →	DEPTOR PSer287	phosphorylation down-regulates ⊣	DEPTOR	22017877	SIGNOR-176887
CSNK1A1	phosphorylation up-regulates →	DEPTOR PSer291	phosphorylation down-regulates ⊣	DEPTOR	22017877	SIGNOR-176879
MTOR	phosphorylation up-regulates →	DEPTOR PSer293	phosphorylation down-regulates ⊣	DEPTOR	22017875	SIGNOR-176849
CSNK1A1	phosphorylation up-regulates →	DEPTOR PSer286	phosphorylation down-regulates ⊣	DEPTOR	22017877	SIGNOR-176871
RPS6KB1	phosphorylation up-regulates →	DEPTOR PSer287	phosphorylation down-regulates ⊣	DEPTOR	22017876	SIGNOR-176862
RPS6KA1	phosphorylation up-regulates →	DEPTOR PSer291	phosphorylation down-regulates ⊣	DEPTOR	22017877	SIGNOR-176891
RPS6KA1	phosphorylation up-regulates →	DEPTOR PSer286	phosphorylation down-regulates ⊣	DEPTOR	22017877	SIGNOR-176883
RPS6K	phosphorylation up-regulates →	DEPTOR PSer291	phosphorylation down-regulates ⊣	DEPTOR	22017877	SIGNOR-252799
MAPK3	phosphorylation up-regulates →	DEPTOR PSer235	phosphorylation up-regulates →	DEPTOR	35216969	SIGNOR-277587
CHKA	phosphorylation up-regulates →	DEPTOR PSer287	phosphorylation down-regulates ⊣	DEPTOR	22017875	SIGNOR-279605
RPS6K	phosphorylation up-regulates →	DEPTOR PSer287	phosphorylation down-regulates ⊣	DEPTOR	22017877	SIGNOR-252798
RPS6KB1	phosphorylation up-regulates →	DEPTOR PSer291	phosphorylation down-regulates ⊣	DEPTOR	22017876	SIGNOR-176866
MTOR	phosphorylation up-regulates →	DEPTOR PSer299	phosphorylation down-regulates ⊣	DEPTOR	22017875	SIGNOR-176853
SYK	phosphorylation up-regulates →	DEPTOR PTyr289	phosphorylation down-regulates ⊣	DEPTOR	34634301	SIGNOR-277572
RPS6K	phosphorylation up-regulates →	DEPTOR PSer286	phosphorylation down-regulates ⊣	DEPTOR	22017877	SIGNOR-252797

Regulator	Mechanism/Effect	Target	SIGNOR-ID
CHKA	phosphorylation down-regulates quantity by destabilization	DEPTOR	SIGNOR-279604
CSNK1A1	phosphorylation down-regulates	DEPTOR	SIGNOR-176875
RPS6KB1	phosphorylation down-regulates	DEPTOR	SIGNOR-176858
RPS6KA1	phosphorylation down-regulates	DEPTOR	SIGNOR-176887
CSNK1A1	phosphorylation down-regulates	DEPTOR	SIGNOR-176879
MTOR	phosphorylation down-regulates	DEPTOR	SIGNOR-176849
CSNK1A1	phosphorylation down-regulates	DEPTOR	SIGNOR-176871
RPS6KB1	phosphorylation down-regulates	DEPTOR	SIGNOR-176862
RPS6KA1	phosphorylation down-regulates	DEPTOR	SIGNOR-176891
RPS6KA1	phosphorylation down-regulates	DEPTOR	SIGNOR-176883
RPS6K	phosphorylation down-regulates	DEPTOR	SIGNOR-252799
MAPK3	phosphorylation → up-regulates quantity by stabilization	DEPTOR	SIGNOR-277587
CHKA	phosphorylation down-regulates quantity by destabilization	DEPTOR	SIGNOR-279605
RPS6K	phosphorylation down-regulates	DEPTOR	SIGNOR-252798
RPS6KB1	phosphorylation down-regulates	DEPTOR	SIGNOR-176866
MTOR	phosphorylation down-regulates	DEPTOR	SIGNOR-176853
SYK	phosphorylation → down-regulates activity	DEPTOR	SIGNOR-277572
RPS6K	phosphorylation down-regulates	DEPTOR	SIGNOR-252797