| Modifier | Substrate | Residue | Sequence | Mechanism/Effect | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| RPS6K | DEPTOR | Ser286 | SSMSSCGsSGYFSSS | phosphorylation down-regulates | 22017877 | SIGNOR-252797 |
| CHKA | DEPTOR | Ser286 | SSMSSCGsSGYFSSS | phosphorylation down-regulates quantity by destabilization | 22017875 | SIGNOR-279604 |
| RPS6KB1 | DEPTOR | Ser286 | SSMSSCGsSGYFSSS | phosphorylation down-regulates | 22017876 | SIGNOR-176858 |
| CSNK1A1 | DEPTOR | Ser286 | SSMSSCGsSGYFSSS | phosphorylation down-regulates | 22017877 | SIGNOR-176871 |
| RPS6KA1 | DEPTOR | Ser286 | SSMSSCGsSGYFSSS | phosphorylation down-regulates | 22017877 | SIGNOR-176883 |
| Enzyme | Effect | Phosphosite | Effect | Target | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| RPS6K | phosphorylation up-regulates → | DEPTOR PSer286 | phosphorylation down-regulates ⊣ | DEPTOR | 22017877 | SIGNOR-252797 |
| CHKA | phosphorylation up-regulates → | DEPTOR PSer286 | phosphorylation down-regulates ⊣ | DEPTOR | 22017875 | SIGNOR-279604 |
| RPS6KB1 | phosphorylation up-regulates → | DEPTOR PSer286 | phosphorylation down-regulates ⊣ | DEPTOR | 22017876 | SIGNOR-176858 |
| CSNK1A1 | phosphorylation up-regulates → | DEPTOR PSer286 | phosphorylation down-regulates ⊣ | DEPTOR | 22017877 | SIGNOR-176871 |
| RPS6KA1 | phosphorylation up-regulates → | DEPTOR PSer286 | phosphorylation down-regulates ⊣ | DEPTOR | 22017877 | SIGNOR-176883 |
| Regulator | Mechanism/Effect | Target | SIGNOR-ID |
|---|---|---|---|
| RPS6K | phosphorylation down-regulates | DEPTOR | SIGNOR-252797 |
| CHKA | phosphorylation down-regulates quantity by destabilization | DEPTOR | SIGNOR-279604 |
| RPS6KB1 | phosphorylation down-regulates | DEPTOR | SIGNOR-176858 |
| CSNK1A1 | phosphorylation down-regulates | DEPTOR | SIGNOR-176871 |
| RPS6KA1 | phosphorylation down-regulates | DEPTOR | SIGNOR-176883 |
