| Modifier | Substrate | Residue | Sequence | Mechanism/Effect | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| CSNK1A1 | DEPTOR | Ser287 | SMSSCGSsGYFSSSP | phosphorylation down-regulates | 22017877 | SIGNOR-176875 |
| RPS6KA1 | DEPTOR | Ser287 | SMSSCGSsGYFSSSP | phosphorylation down-regulates | 22017877 | SIGNOR-176887 |
| RPS6KB1 | DEPTOR | Ser287 | SMSSCGSsGYFSSSP | phosphorylation down-regulates | 22017876 | SIGNOR-176862 |
| CHKA | DEPTOR | Ser287 | SMSSCGSsGYFSSSP | phosphorylation down-regulates quantity by destabilization | 22017875 | SIGNOR-279605 |
| RPS6K | DEPTOR | Ser287 | SMSSCGSsGYFSSSP | phosphorylation down-regulates | 22017877 | SIGNOR-252798 |
| Enzyme | Effect | Phosphosite | Effect | Target | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| CSNK1A1 | phosphorylation up-regulates → | DEPTOR PSer287 | phosphorylation down-regulates ⊣ | DEPTOR | 22017877 | SIGNOR-176875 |
| RPS6KA1 | phosphorylation up-regulates → | DEPTOR PSer287 | phosphorylation down-regulates ⊣ | DEPTOR | 22017877 | SIGNOR-176887 |
| RPS6KB1 | phosphorylation up-regulates → | DEPTOR PSer287 | phosphorylation down-regulates ⊣ | DEPTOR | 22017876 | SIGNOR-176862 |
| CHKA | phosphorylation up-regulates → | DEPTOR PSer287 | phosphorylation down-regulates ⊣ | DEPTOR | 22017875 | SIGNOR-279605 |
| RPS6K | phosphorylation up-regulates → | DEPTOR PSer287 | phosphorylation down-regulates ⊣ | DEPTOR | 22017877 | SIGNOR-252798 |
| Regulator | Mechanism/Effect | Target | SIGNOR-ID |
|---|---|---|---|
| CSNK1A1 | phosphorylation down-regulates | DEPTOR | SIGNOR-176875 |
| RPS6KA1 | phosphorylation down-regulates | DEPTOR | SIGNOR-176887 |
| RPS6KB1 | phosphorylation down-regulates | DEPTOR | SIGNOR-176862 |
| CHKA | phosphorylation down-regulates quantity by destabilization | DEPTOR | SIGNOR-279605 |
| RPS6K | phosphorylation down-regulates | DEPTOR | SIGNOR-252798 |
