| Modifier | Substrate | Residue | Sequence | Mechanism/Effect | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| CSNK1A1 | DEPTOR | Ser291 | CGSSGYFsSSPTLSS | phosphorylation down-regulates | 22017877 | SIGNOR-176879 |
| RPS6KA1 | DEPTOR | Ser291 | CGSSGYFsSSPTLSS | phosphorylation down-regulates | 22017877 | SIGNOR-176891 |
| RPS6K | DEPTOR | Ser291 | CGSSGYFsSSPTLSS | phosphorylation down-regulates | 22017877 | SIGNOR-252799 |
| RPS6KB1 | DEPTOR | Ser291 | CGSSGYFsSSPTLSS | phosphorylation down-regulates | 22017876 | SIGNOR-176866 |
| Enzyme | Effect | Phosphosite | Effect | Target | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| CSNK1A1 | phosphorylation up-regulates → | DEPTOR PSer291 | phosphorylation down-regulates ⊣ | DEPTOR | 22017877 | SIGNOR-176879 |
| RPS6KA1 | phosphorylation up-regulates → | DEPTOR PSer291 | phosphorylation down-regulates ⊣ | DEPTOR | 22017877 | SIGNOR-176891 |
| RPS6K | phosphorylation up-regulates → | DEPTOR PSer291 | phosphorylation down-regulates ⊣ | DEPTOR | 22017877 | SIGNOR-252799 |
| RPS6KB1 | phosphorylation up-regulates → | DEPTOR PSer291 | phosphorylation down-regulates ⊣ | DEPTOR | 22017876 | SIGNOR-176866 |
| Regulator | Mechanism/Effect | Target | SIGNOR-ID |
|---|---|---|---|
| CSNK1A1 | phosphorylation down-regulates | DEPTOR | SIGNOR-176879 |
| RPS6KA1 | phosphorylation down-regulates | DEPTOR | SIGNOR-176891 |
| RPS6K | phosphorylation down-regulates | DEPTOR | SIGNOR-252799 |
| RPS6KB1 | phosphorylation down-regulates | DEPTOR | SIGNOR-176866 |
