| Modifier | Substrate | Residue | Sequence | Mechanism/Effect | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| PPP2CA | MAPK15 | Thr175 | GPEDQAVtEYVATRW | dephosphorylation down-regulates | 16336213 | SIGNOR-142977 |
| MAPK15 | MAPK15 | Thr175 | GPEDQAVtEYVATRW | phosphorylation up-regulates | 16336213 | SIGNOR-142969 |
| Enzyme | Effect | Phosphosite | Effect | Target | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| PPP2CA | dephosphorylation down-regulates ⊣ | MAPK15 PThr175 | dephosphorylation up-regulates → | MAPK15 | 16336213 | SIGNOR-142977 |
| MAPK15 | phosphorylation up-regulates → | MAPK15 PThr175 | phosphorylation up-regulates → | MAPK15 | 16336213 | SIGNOR-142969 |
| Regulator | Mechanism/Effect | Target | SIGNOR-ID |
|---|---|---|---|
| PPP2CA | dephosphorylation down-regulates | MAPK15 | SIGNOR-142977 |
| MAPK15 | phosphorylation → up-regulates | MAPK15 | SIGNOR-142969 |
