| Modifier | Substrate | Residue | Sequence | Mechanism/Effect | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| PTPN1 | MAPK15 | Tyr177 | EDQAVTEyVATRWYR | dephosphorylation down-regulates | 16336213 | SIGNOR-142981 |
| MAPK15 | MAPK15 | Tyr177 | EDQAVTEyVATRWYR | phosphorylation up-regulates | 16336213 | SIGNOR-142973 |
| Enzyme | Effect | Phosphosite | Effect | Target | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| PTPN1 | dephosphorylation down-regulates ⊣ | MAPK15 PTyr177 | dephosphorylation up-regulates → | MAPK15 | 16336213 | SIGNOR-142981 |
| MAPK15 | phosphorylation up-regulates → | MAPK15 PTyr177 | phosphorylation up-regulates → | MAPK15 | 16336213 | SIGNOR-142973 |
| Regulator | Mechanism/Effect | Target | SIGNOR-ID |
|---|---|---|---|
| PTPN1 | dephosphorylation down-regulates | MAPK15 | SIGNOR-142981 |
| MAPK15 | phosphorylation → up-regulates | MAPK15 | SIGNOR-142973 |
