Modifier	Substrate	Residue	Sequence	Mechanism/Effect	PMID	Interaction ID
BRSK1	CAST	Ser45	KSQSTKLsVVHEKKS	phosphorylation up-regulates activity	27626661	SIGNOR-263051
BRSK1	TUBG1	Ser131	READGSDsLEGFVLC	phosphorylation up-regulates	19648910	SIGNOR-187405
BRSK1	WEE1	Ser642	KKMNRSVsLTIY	phosphorylation unknown	15150265	SIGNOR-250601
BRSK1	CDC25B	Ser375	ARVLRSKsLCHDEIE	phosphorylation down-regulates	15150265	SIGNOR-124839
BRSK1	CDC25B	Ser375	ARVLRSKsLCHDEIE	phosphorylation down-regulates activity	15150265	SIGNOR-107404
BRSK1	CDC25C	Ser216	SGLYRSPsMPENLNR	phosphorylation down-regulates	9543386	SIGNOR-56473
BRSK1	CDC25C	Ser216	SGLYRSPsMPENLNR	phosphorylation down-regulates activity	15150265	SIGNOR-107408

Enzyme	Effect	Phosphosite	Effect	Target	PMID	Interaction ID
BRSK1	phosphorylation up-regulates →	CAST PSer45	phosphorylation up-regulates →	CAST	27626661	SIGNOR-263051
BRSK1	phosphorylation up-regulates →	TUBG1 PSer131	phosphorylation up-regulates →	TUBG1	19648910	SIGNOR-187405
BRSK1	phosphorylation up-regulates →	WEE1 PSer642	phosphorylation down-regulates ⊣	WEE1	15150265	SIGNOR-250601
BRSK1	phosphorylation up-regulates →	CDC25B PSer375	phosphorylation down-regulates ⊣	CDC25B	15150265	SIGNOR-124839
BRSK1	phosphorylation up-regulates →	CDC25B PSer375	phosphorylation down-regulates ⊣	CDC25B	15150265	SIGNOR-107404
BRSK1	phosphorylation up-regulates →	CDC25C PSer216	phosphorylation down-regulates ⊣	CDC25C	9543386	SIGNOR-56473
BRSK1	phosphorylation up-regulates →	CDC25C PSer216	phosphorylation down-regulates ⊣	CDC25C	15150265	SIGNOR-107408

Regulator	Mechanism/Effect	Target	SIGNOR-ID
BRSK1	phosphorylation → up-regulates activity	CAST	SIGNOR-263051
BRSK1	phosphorylation → up-regulates	TUBG1	SIGNOR-187405
BRSK1	phosphorylation → unknown	WEE1	SIGNOR-250601
BRSK1	phosphorylation down-regulates	CDC25B	SIGNOR-124839
BRSK1	phosphorylation → down-regulates activity	CDC25B	SIGNOR-107404
BRSK1	phosphorylation down-regulates	CDC25C	SIGNOR-56473
BRSK1	phosphorylation → down-regulates activity	CDC25C	SIGNOR-107408