| Name | GRK7 |
| ID | Q8WTQ7 |
| Role | substrate |
| Enzymatic Domains |
RGS 56-176 PROSITE-ProRule
Protein kinase 191-454 PROSITE-ProRule
AGC-kinase C-terminal 455-520 PROSITE-ProRule |
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| Modifier | Substrate | Residue | Sequence | Mechanism/Effect | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| PKA | GRK7 | Ser23 | YLQARKPsDCDSKEL | phosphorylation down-regulates activity | 15946941 | SIGNOR-276036 |
| GRK7 | GRK7 | Ser490 | YAKDIAEiDDFSEVR | phosphorylation unknown | 15946941 | SIGNOR-260838 |
| PKA | GRK7 | Ser23 | YLQARKPsDCDSKEL | phosphorylation down-regulates activity | 15946941 | SIGNOR-260839 |
| PKA | GRK7 | Ser36 | ELQRRRRsLALPGLQ | phosphorylation down-regulates activity | 15946941 | SIGNOR-276035 |
| PKA | GRK7 | Ser23 | YLQARKPsDCDSKEL | phosphorylation down-regulates activity | 15946941 | SIGNOR-274081 |
| PKA | GRK7 | Ser36 | ELQRRRRsLALPGLQ | phosphorylation down-regulates activity | 15946941 | SIGNOR-274080 |
| PKA | GRK7 | Ser36 | ELQRRRRsLALPGLQ | phosphorylation up-regulates activity | 18803695 | SIGNOR-263152 |
| PKA | GRK7 | Ser36 | ELQRRRRsLALPGLQ | phosphorylation down-regulates activity | 15946941 | SIGNOR-260840 |
| Enzyme | Effect | Phosphosite | Effect | Target | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| PKA | phosphorylation up-regulates → | GRK7 PSer23 | phosphorylation down-regulates ⊣ | GRK7 | 15946941 | SIGNOR-276036 |
| GRK7 | phosphorylation up-regulates → | GRK7 PSer490 | phosphorylation down-regulates ⊣ | GRK7 | 15946941 | SIGNOR-260838 |
| PKA | phosphorylation up-regulates → | GRK7 PSer23 | phosphorylation down-regulates ⊣ | GRK7 | 15946941 | SIGNOR-260839 |
| PKA | phosphorylation up-regulates → | GRK7 PSer36 | phosphorylation down-regulates ⊣ | GRK7 | 15946941 | SIGNOR-276035 |
| PKA | phosphorylation up-regulates → | GRK7 PSer23 | phosphorylation down-regulates ⊣ | GRK7 | 15946941 | SIGNOR-274081 |
| PKA | phosphorylation up-regulates → | GRK7 PSer36 | phosphorylation down-regulates ⊣ | GRK7 | 15946941 | SIGNOR-274080 |
| PKA | phosphorylation up-regulates → | GRK7 PSer36 | phosphorylation up-regulates → | GRK7 | 18803695 | SIGNOR-263152 |
| PKA | phosphorylation up-regulates → | GRK7 PSer36 | phosphorylation down-regulates ⊣ | GRK7 | 15946941 | SIGNOR-260840 |
| Regulator | Mechanism/Effect | Target | SIGNOR-ID |
|---|---|---|---|
| PKA | phosphorylation → down-regulates activity | GRK7 | SIGNOR-276036 |
| GRK7 | phosphorylation → unknown | GRK7 | SIGNOR-260838 |
| PKA | phosphorylation → down-regulates activity | GRK7 | SIGNOR-260839 |
| PKA | phosphorylation → down-regulates activity | GRK7 | SIGNOR-276035 |
| PKA | phosphorylation → down-regulates activity | GRK7 | SIGNOR-274081 |
| PKA | phosphorylation → down-regulates activity | GRK7 | SIGNOR-274080 |
| PKA | phosphorylation → up-regulates activity | GRK7 | SIGNOR-263152 |
| PKA | phosphorylation → down-regulates activity | GRK7 | SIGNOR-260840 |