| Modifier | Substrate | Residue | Sequence | Mechanism/Effect | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| PKA | GRK7 | Ser36 | ELQRRRRsLALPGLQ | phosphorylation down-regulates activity | 15946941 | SIGNOR-274080 |
| PKA | GRK7 | Ser36 | ELQRRRRsLALPGLQ | phosphorylation up-regulates activity | 18803695 | SIGNOR-263152 |
| PKA | GRK7 | Ser36 | ELQRRRRsLALPGLQ | phosphorylation down-regulates activity | 15946941 | SIGNOR-260840 |
| PKA | GRK7 | Ser36 | ELQRRRRsLALPGLQ | phosphorylation down-regulates activity | 15946941 | SIGNOR-276035 |
| Enzyme | Effect | Phosphosite | Effect | Target | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| PKA | phosphorylation up-regulates → | GRK7 PSer36 | phosphorylation down-regulates ⊣ | GRK7 | 15946941 | SIGNOR-274080 |
| PKA | phosphorylation up-regulates → | GRK7 PSer36 | phosphorylation up-regulates → | GRK7 | 18803695 | SIGNOR-263152 |
| PKA | phosphorylation up-regulates → | GRK7 PSer36 | phosphorylation down-regulates ⊣ | GRK7 | 15946941 | SIGNOR-260840 |
| PKA | phosphorylation up-regulates → | GRK7 PSer36 | phosphorylation down-regulates ⊣ | GRK7 | 15946941 | SIGNOR-276035 |
| Regulator | Mechanism/Effect | Target | SIGNOR-ID |
|---|---|---|---|
| PKA | phosphorylation → down-regulates activity | GRK7 | SIGNOR-274080 |
| PKA | phosphorylation → up-regulates activity | GRK7 | SIGNOR-263152 |
| PKA | phosphorylation → down-regulates activity | GRK7 | SIGNOR-260840 |
| PKA | phosphorylation → down-regulates activity | GRK7 | SIGNOR-276035 |