Entity Details

Name FRS2
ID Q8WU20
Role substrate
Enzymatic Domains
IRS-type PTB 13-115
PROSITE-ProRule
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Data Summary
PTM Format
SIGNOR Summary
Modifier Substrate Residue Sequence Mechanism/Effect PMID Interaction ID
FGFR1FRS2Tyr196AEEQVHTyVNTTGVQphosphorylation
up-regulates activity		25394172SIGNOR-280013
FGFR1FRS2–phosphorylation
up-regulates activity		9182757SIGNOR-236944
INSRFRS2–phosphorylation
up-regulates activity		10650943SIGNOR-278945
FGFR4FRS2–phosphorylation
up-regulates activity		9182757SIGNOR-242661
FGFR2FRS2–phosphorylation
up-regulates activity		9182757SIGNOR-236950
Enzyme Effect Phosphosite Effect Target PMID Interaction ID
FGFR1phosphorylation
up-regulates
→
FRS2
PTyr196		phosphorylation
up-regulates
→		FRS225394172SIGNOR-280013
Regulator Mechanism/Effect Target SIGNOR-ID
FGFR1phosphorylation
→
up-regulates activity 		FRS2SIGNOR-280013
FGFR1phosphorylation
→
up-regulates activity 		FRS2SIGNOR-236944
INSRphosphorylation
→
up-regulates activity 		FRS2SIGNOR-278945
FGFR4phosphorylation
→
up-regulates activity 		FRS2SIGNOR-242661
FGFR2phosphorylation
→
up-regulates activity 		FRS2SIGNOR-236950