| Modifier | Substrate | Residue | Sequence | Mechanism/Effect | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| PRKD3 | HDAC7 | Ser358 | WPLSRTRsEPLPPSA | phosphorylation up-regulates activity | 18692497 | SIGNOR-275934 |
| PPP2CB | HDAC7 | Ser155 | FPLRKTVsEPNLKLR | dephosphorylation up-regulates activity | 18339811 | SIGNOR-248603 |
| PPP2CA | HDAC7 | Ser155 | FPLRKTVsEPNLKLR | dephosphorylation up-regulates activity | 18339811 | SIGNOR-248646 |
| PRKD1 | HDAC7 | Ser486 | RPLSRAQsSPAAPAS | phosphorylation down-regulates | 18617643 | SIGNOR-179430 |
| PPP2CB | HDAC7 | Ser181 | NPLLRKEsAPPSLRR | dephosphorylation up-regulates activity | 18339811 | SIGNOR-248604 |
| PRKD1 | HDAC7 | Ser486 | RPLSRAQsSPAAPAS | phosphorylation down-regulates | 18509061 | SIGNOR-178713 |
| PRKD2 | HDAC7 | Ser358 | WPLSRTRsEPLPPSA | phosphorylation up-regulates activity | 18692497 | SIGNOR-275935 |
| PRKAA1 | HDAC7 | Ser358 | WPLSRTRsEPLPPSA | phosphorylation down-regulates | 21892142 | SIGNOR-176491 |
| AMPK | HDAC7 | Ser155 | FPLRKTVsEPNLKLR | phosphorylation down-regulates | 21892142 | SIGNOR-216554 |
| PRKD1 | HDAC7 | Ser358 | WPLSRTRsEPLPPSA | phosphorylation unknown | 15738054 | SIGNOR-249274 |
| PRKD2 | HDAC7 | Ser155 | FPLRKTVsEPNLKLR | phosphorylation up-regulates activity | 18692497 | SIGNOR-275933 |
| PPP2CA | HDAC7 | Ser486 | RPLSRAQsSPAAPAS | dephosphorylation up-regulates activity | 18339811 | SIGNOR-248649 |
| MAP3K7 | HDAC7 | Ser155 | FPLRKTVsEPNLKLR | phosphorylation down-regulates | 16980613 | SIGNOR-149579 |
| PRKD1 | HDAC7 | Ser358 | WPLSRTRsEPLPPSA | phosphorylation down-regulates | 15623513 | SIGNOR-132898 |
| PRKAA1 | HDAC7 | Ser155 | FPLRKTVsEPNLKLR | phosphorylation down-regulates | 21892142 | SIGNOR-176487 |
| PPP2CB | HDAC7 | Ser486 | RPLSRAQsSPAAPAS | dephosphorylation up-regulates activity | 18339811 | SIGNOR-248606 |
| PRKD1 | HDAC7 | Ser181 | NPLLRKEsAPPSLRR | phosphorylation unknown | 15738054 | SIGNOR-249273 |
| PPP2CA | HDAC7 | Ser358 | WPLSRTRsEPLPPSA | dephosphorylation up-regulates activity | 18339811 | SIGNOR-248648 |
| AMPK | HDAC7 | Ser358 | WPLSRTRsEPLPPSA | phosphorylation down-regulates | 21892142 | SIGNOR-216558 |
| PRKD1 | HDAC7 | Ser486 | RPLSRAQsSPAAPAS | phosphorylation unknown | 15738054 | SIGNOR-249276 |
| PRKD1 | HDAC7 | Ser155 | FPLRKTVsEPNLKLR | phosphorylation unknown | 15738054 | SIGNOR-249275 |
| MARK2 | HDAC7 | Ser155 | FPLRKTVsEPNLKLR | phosphorylation down-regulates | 16980613 | SIGNOR-149583 |
| PPP2CA | HDAC7 | Ser181 | NPLLRKEsAPPSLRR | dephosphorylation up-regulates activity | 18339811 | SIGNOR-248647 |
| PRKD1 | HDAC7 | Ser155 | FPLRKTVsEPNLKLR | phosphorylation down-regulates | 15623513 | SIGNOR-132894 |
| PRKD1 | HDAC7 | Ser486 | RPLSRAQsSPAAPAS | phosphorylation down-regulates | 15623513 | SIGNOR-132902 |
| PRKD3 | HDAC7 | Ser155 | FPLRKTVsEPNLKLR | phosphorylation up-regulates activity | 18692497 | SIGNOR-275932 |
| PPP2CB | HDAC7 | Ser358 | WPLSRTRsEPLPPSA | dephosphorylation up-regulates activity | 18339811 | SIGNOR-248605 |
| Enzyme | Effect | Phosphosite | Effect | Target | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| PRKD3 | phosphorylation up-regulates → | HDAC7 PSer358 | phosphorylation up-regulates → | HDAC7 | 18692497 | SIGNOR-275934 |
| PPP2CB | dephosphorylation down-regulates ⊣ | HDAC7 PSer155 | dephosphorylation down-regulates ⊣ | HDAC7 | 18339811 | SIGNOR-248603 |
| PPP2CA | dephosphorylation down-regulates ⊣ | HDAC7 PSer155 | dephosphorylation down-regulates ⊣ | HDAC7 | 18339811 | SIGNOR-248646 |
| PRKD1 | phosphorylation up-regulates → | HDAC7 PSer486 | phosphorylation down-regulates ⊣ | HDAC7 | 18617643 | SIGNOR-179430 |
| PPP2CB | dephosphorylation down-regulates ⊣ | HDAC7 PSer181 | dephosphorylation down-regulates ⊣ | HDAC7 | 18339811 | SIGNOR-248604 |
| PRKD1 | phosphorylation up-regulates → | HDAC7 PSer486 | phosphorylation down-regulates ⊣ | HDAC7 | 18509061 | SIGNOR-178713 |
| PRKD2 | phosphorylation up-regulates → | HDAC7 PSer358 | phosphorylation up-regulates → | HDAC7 | 18692497 | SIGNOR-275935 |
| PRKAA1 | phosphorylation up-regulates → | HDAC7 PSer358 | phosphorylation down-regulates ⊣ | HDAC7 | 21892142 | SIGNOR-176491 |
| AMPK | phosphorylation up-regulates → | HDAC7 PSer155 | phosphorylation down-regulates ⊣ | HDAC7 | 21892142 | SIGNOR-216554 |
| PRKD1 | phosphorylation up-regulates → | HDAC7 PSer358 | phosphorylation down-regulates ⊣ | HDAC7 | 15738054 | SIGNOR-249274 |
| PRKD2 | phosphorylation up-regulates → | HDAC7 PSer155 | phosphorylation up-regulates → | HDAC7 | 18692497 | SIGNOR-275933 |
| PPP2CA | dephosphorylation down-regulates ⊣ | HDAC7 PSer486 | dephosphorylation down-regulates ⊣ | HDAC7 | 18339811 | SIGNOR-248649 |
| MAP3K7 | phosphorylation up-regulates → | HDAC7 PSer155 | phosphorylation down-regulates ⊣ | HDAC7 | 16980613 | SIGNOR-149579 |
| PRKD1 | phosphorylation up-regulates → | HDAC7 PSer358 | phosphorylation down-regulates ⊣ | HDAC7 | 15623513 | SIGNOR-132898 |
| PRKAA1 | phosphorylation up-regulates → | HDAC7 PSer155 | phosphorylation down-regulates ⊣ | HDAC7 | 21892142 | SIGNOR-176487 |
| PPP2CB | dephosphorylation down-regulates ⊣ | HDAC7 PSer486 | dephosphorylation down-regulates ⊣ | HDAC7 | 18339811 | SIGNOR-248606 |
| PRKD1 | phosphorylation up-regulates → | HDAC7 PSer181 | phosphorylation down-regulates ⊣ | HDAC7 | 15738054 | SIGNOR-249273 |
| PPP2CA | dephosphorylation down-regulates ⊣ | HDAC7 PSer358 | dephosphorylation down-regulates ⊣ | HDAC7 | 18339811 | SIGNOR-248648 |
| AMPK | phosphorylation up-regulates → | HDAC7 PSer358 | phosphorylation down-regulates ⊣ | HDAC7 | 21892142 | SIGNOR-216558 |
| PRKD1 | phosphorylation up-regulates → | HDAC7 PSer486 | phosphorylation down-regulates ⊣ | HDAC7 | 15738054 | SIGNOR-249276 |
| PRKD1 | phosphorylation up-regulates → | HDAC7 PSer155 | phosphorylation down-regulates ⊣ | HDAC7 | 15738054 | SIGNOR-249275 |
| MARK2 | phosphorylation up-regulates → | HDAC7 PSer155 | phosphorylation down-regulates ⊣ | HDAC7 | 16980613 | SIGNOR-149583 |
| PPP2CA | dephosphorylation down-regulates ⊣ | HDAC7 PSer181 | dephosphorylation down-regulates ⊣ | HDAC7 | 18339811 | SIGNOR-248647 |
| PRKD1 | phosphorylation up-regulates → | HDAC7 PSer155 | phosphorylation down-regulates ⊣ | HDAC7 | 15623513 | SIGNOR-132894 |
| PRKD1 | phosphorylation up-regulates → | HDAC7 PSer486 | phosphorylation down-regulates ⊣ | HDAC7 | 15623513 | SIGNOR-132902 |
| PRKD3 | phosphorylation up-regulates → | HDAC7 PSer155 | phosphorylation up-regulates → | HDAC7 | 18692497 | SIGNOR-275932 |
| PPP2CB | dephosphorylation down-regulates ⊣ | HDAC7 PSer358 | dephosphorylation down-regulates ⊣ | HDAC7 | 18339811 | SIGNOR-248605 |
| Regulator | Mechanism/Effect | Target | SIGNOR-ID |
|---|---|---|---|
| PRKD3 | phosphorylation → up-regulates activity | HDAC7 | SIGNOR-275934 |
| PPP2CB | dephosphorylation → up-regulates activity | HDAC7 | SIGNOR-248603 |
| PPP2CA | dephosphorylation → up-regulates activity | HDAC7 | SIGNOR-248646 |
| PRKD1 | phosphorylation down-regulates | HDAC7 | SIGNOR-179430 |
| PPP2CB | dephosphorylation → up-regulates activity | HDAC7 | SIGNOR-248604 |
| PRKD1 | phosphorylation down-regulates | HDAC7 | SIGNOR-178713 |
| PRKD2 | phosphorylation → up-regulates activity | HDAC7 | SIGNOR-275935 |
| PRKAA1 | phosphorylation down-regulates | HDAC7 | SIGNOR-176491 |
| AMPK | phosphorylation down-regulates | HDAC7 | SIGNOR-216554 |
| PRKD1 | phosphorylation → unknown | HDAC7 | SIGNOR-249274 |
| PRKD2 | phosphorylation → up-regulates activity | HDAC7 | SIGNOR-275933 |
| PPP2CA | dephosphorylation → up-regulates activity | HDAC7 | SIGNOR-248649 |
| MAP3K7 | phosphorylation down-regulates | HDAC7 | SIGNOR-149579 |
| PRKD1 | phosphorylation down-regulates | HDAC7 | SIGNOR-132898 |
| PRKAA1 | phosphorylation down-regulates | HDAC7 | SIGNOR-176487 |
| PPP2CB | dephosphorylation → up-regulates activity | HDAC7 | SIGNOR-248606 |
| PRKD1 | phosphorylation → unknown | HDAC7 | SIGNOR-249273 |
| PPP2CA | dephosphorylation → up-regulates activity | HDAC7 | SIGNOR-248648 |
| AMPK | phosphorylation down-regulates | HDAC7 | SIGNOR-216558 |
| PRKD1 | phosphorylation → unknown | HDAC7 | SIGNOR-249276 |
| PRKD1 | phosphorylation → unknown | HDAC7 | SIGNOR-249275 |
| MARK2 | phosphorylation down-regulates | HDAC7 | SIGNOR-149583 |
| PPP2CA | dephosphorylation → up-regulates activity | HDAC7 | SIGNOR-248647 |
| PRKD1 | phosphorylation down-regulates | HDAC7 | SIGNOR-132894 |
| PRKD1 | phosphorylation down-regulates | HDAC7 | SIGNOR-132902 |
| PRKD3 | phosphorylation → up-regulates activity | HDAC7 | SIGNOR-275932 |
| PPP2CB | dephosphorylation → up-regulates activity | HDAC7 | SIGNOR-248605 |
