| Modifier | Substrate | Residue | Sequence | Mechanism/Effect | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| PPP2CA | HDAC7 | Ser358 | WPLSRTRsEPLPPSA | dephosphorylation up-regulates activity | 18339811 | SIGNOR-248648 |
| PRKD3 | HDAC7 | Ser358 | WPLSRTRsEPLPPSA | phosphorylation up-regulates activity | 18692497 | SIGNOR-275934 |
| PPP2CB | HDAC7 | Ser358 | WPLSRTRsEPLPPSA | dephosphorylation up-regulates activity | 18339811 | SIGNOR-248605 |
| PRKD2 | HDAC7 | Ser358 | WPLSRTRsEPLPPSA | phosphorylation up-regulates activity | 18692497 | SIGNOR-275935 |
| PRKD1 | HDAC7 | Ser358 | WPLSRTRsEPLPPSA | phosphorylation unknown | 15738054 | SIGNOR-249274 |
| PRKD1 | HDAC7 | Ser358 | WPLSRTRsEPLPPSA | phosphorylation down-regulates | 15623513 | SIGNOR-132898 |
| AMPK | HDAC7 | Ser358 | WPLSRTRsEPLPPSA | phosphorylation down-regulates | 21892142 | SIGNOR-216558 |
| PRKAA1 | HDAC7 | Ser358 | WPLSRTRsEPLPPSA | phosphorylation down-regulates | 21892142 | SIGNOR-176491 |
| Enzyme | Effect | Phosphosite | Effect | Target | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| PPP2CA | dephosphorylation down-regulates ⊣ | HDAC7 PSer358 | dephosphorylation down-regulates ⊣ | HDAC7 | 18339811 | SIGNOR-248648 |
| PRKD3 | phosphorylation up-regulates → | HDAC7 PSer358 | phosphorylation up-regulates → | HDAC7 | 18692497 | SIGNOR-275934 |
| PPP2CB | dephosphorylation down-regulates ⊣ | HDAC7 PSer358 | dephosphorylation down-regulates ⊣ | HDAC7 | 18339811 | SIGNOR-248605 |
| PRKD2 | phosphorylation up-regulates → | HDAC7 PSer358 | phosphorylation up-regulates → | HDAC7 | 18692497 | SIGNOR-275935 |
| PRKD1 | phosphorylation up-regulates → | HDAC7 PSer358 | phosphorylation down-regulates ⊣ | HDAC7 | 15738054 | SIGNOR-249274 |
| PRKD1 | phosphorylation up-regulates → | HDAC7 PSer358 | phosphorylation down-regulates ⊣ | HDAC7 | 15623513 | SIGNOR-132898 |
| AMPK | phosphorylation up-regulates → | HDAC7 PSer358 | phosphorylation down-regulates ⊣ | HDAC7 | 21892142 | SIGNOR-216558 |
| PRKAA1 | phosphorylation up-regulates → | HDAC7 PSer358 | phosphorylation down-regulates ⊣ | HDAC7 | 21892142 | SIGNOR-176491 |
| Regulator | Mechanism/Effect | Target | SIGNOR-ID |
|---|---|---|---|
| PPP2CA | dephosphorylation → up-regulates activity | HDAC7 | SIGNOR-248648 |
| PRKD3 | phosphorylation → up-regulates activity | HDAC7 | SIGNOR-275934 |
| PPP2CB | dephosphorylation → up-regulates activity | HDAC7 | SIGNOR-248605 |
| PRKD2 | phosphorylation → up-regulates activity | HDAC7 | SIGNOR-275935 |
| PRKD1 | phosphorylation → unknown | HDAC7 | SIGNOR-249274 |
| PRKD1 | phosphorylation down-regulates | HDAC7 | SIGNOR-132898 |
| AMPK | phosphorylation down-regulates | HDAC7 | SIGNOR-216558 |
| PRKAA1 | phosphorylation down-regulates | HDAC7 | SIGNOR-176491 |
