| Modifier | Substrate | Residue | Sequence | Mechanism/Effect | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| PRKD1 | HDAC7 | Ser486 | RPLSRAQsSPAAPAS | phosphorylation down-regulates | 15623513 | SIGNOR-132902 |
| PPP2CB | HDAC7 | Ser486 | RPLSRAQsSPAAPAS | dephosphorylation up-regulates activity | 18339811 | SIGNOR-248606 |
| PRKD1 | HDAC7 | Ser486 | RPLSRAQsSPAAPAS | phosphorylation down-regulates | 18617643 | SIGNOR-179430 |
| PRKD1 | HDAC7 | Ser486 | RPLSRAQsSPAAPAS | phosphorylation down-regulates | 18509061 | SIGNOR-178713 |
| PPP2CA | HDAC7 | Ser486 | RPLSRAQsSPAAPAS | dephosphorylation up-regulates activity | 18339811 | SIGNOR-248649 |
| PRKD1 | HDAC7 | Ser486 | RPLSRAQsSPAAPAS | phosphorylation unknown | 15738054 | SIGNOR-249276 |
| Enzyme | Effect | Phosphosite | Effect | Target | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| PRKD1 | phosphorylation up-regulates → | HDAC7 PSer486 | phosphorylation down-regulates ⊣ | HDAC7 | 15623513 | SIGNOR-132902 |
| PPP2CB | dephosphorylation down-regulates ⊣ | HDAC7 PSer486 | dephosphorylation down-regulates ⊣ | HDAC7 | 18339811 | SIGNOR-248606 |
| PRKD1 | phosphorylation up-regulates → | HDAC7 PSer486 | phosphorylation down-regulates ⊣ | HDAC7 | 18617643 | SIGNOR-179430 |
| PRKD1 | phosphorylation up-regulates → | HDAC7 PSer486 | phosphorylation down-regulates ⊣ | HDAC7 | 18509061 | SIGNOR-178713 |
| PPP2CA | dephosphorylation down-regulates ⊣ | HDAC7 PSer486 | dephosphorylation down-regulates ⊣ | HDAC7 | 18339811 | SIGNOR-248649 |
| PRKD1 | phosphorylation up-regulates → | HDAC7 PSer486 | phosphorylation down-regulates ⊣ | HDAC7 | 15738054 | SIGNOR-249276 |
| Regulator | Mechanism/Effect | Target | SIGNOR-ID |
|---|---|---|---|
| PRKD1 | phosphorylation down-regulates | HDAC7 | SIGNOR-132902 |
| PPP2CB | dephosphorylation → up-regulates activity | HDAC7 | SIGNOR-248606 |
| PRKD1 | phosphorylation down-regulates | HDAC7 | SIGNOR-179430 |
| PRKD1 | phosphorylation down-regulates | HDAC7 | SIGNOR-178713 |
| PPP2CA | dephosphorylation → up-regulates activity | HDAC7 | SIGNOR-248649 |
| PRKD1 | phosphorylation → unknown | HDAC7 | SIGNOR-249276 |
