| Modifier | Substrate | Residue | Sequence | Mechanism/Effect | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| PPP2CA | HDAC7 | Ser181 | NPLLRKEsAPPSLRR | dephosphorylation up-regulates activity | 18339811 | SIGNOR-248647 |
| PRKD1 | HDAC7 | Ser181 | NPLLRKEsAPPSLRR | phosphorylation unknown | 15738054 | SIGNOR-249273 |
| PPP2CB | HDAC7 | Ser181 | NPLLRKEsAPPSLRR | dephosphorylation up-regulates activity | 18339811 | SIGNOR-248604 |
| Enzyme | Effect | Phosphosite | Effect | Target | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| PPP2CA | dephosphorylation down-regulates ⊣ | HDAC7 PSer181 | dephosphorylation down-regulates ⊣ | HDAC7 | 18339811 | SIGNOR-248647 |
| PRKD1 | phosphorylation up-regulates → | HDAC7 PSer181 | phosphorylation down-regulates ⊣ | HDAC7 | 15738054 | SIGNOR-249273 |
| PPP2CB | dephosphorylation down-regulates ⊣ | HDAC7 PSer181 | dephosphorylation down-regulates ⊣ | HDAC7 | 18339811 | SIGNOR-248604 |
| Regulator | Mechanism/Effect | Target | SIGNOR-ID |
|---|---|---|---|
| PPP2CA | dephosphorylation → up-regulates activity | HDAC7 | SIGNOR-248647 |
| PRKD1 | phosphorylation → unknown | HDAC7 | SIGNOR-249273 |
| PPP2CB | dephosphorylation → up-regulates activity | HDAC7 | SIGNOR-248604 |
